2017
DOI: 10.3389/fcimb.2017.00251
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Transcriptomic Analysis on Responses of Murine Lungs to Pasteurella multocida Infection

Abstract: Pasteurella multocida infection in cattle causes serious epidemic diseases and leads to great economic losses in livestock industry; however, little is known about the interaction between host and P. multocida in the lungs. To explore a fully insight into the host responses in the lungs during P. multocida infection, a mouse model of Pasteurella pneumonia was established by intraperitoneal infection, and then transcriptomic analysis of infected lungs was performed. P. multocida localized and grew in murine lun… Show more

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Cited by 36 publications
(52 citation statements)
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References 87 publications
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“…In the current study, genes (FAS, APAF1, TNFRSF1A, CASP7, and CASP8) related to apoptosis were significantly upregulated in PmQ infected chickens but not in chickens infected with PmCQ2. In contrast to our previous study, the apoptosis pathway is enriched in PmCQ2 infected mice with a deadly outcome (14). Together, these results hint that the PmQ infected chicken attempt to cause cell death of the host, leading to tissue lesions of the lungs.…”
Section: Discussioncontrasting
confidence: 91%
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“…In the current study, genes (FAS, APAF1, TNFRSF1A, CASP7, and CASP8) related to apoptosis were significantly upregulated in PmQ infected chickens but not in chickens infected with PmCQ2. In contrast to our previous study, the apoptosis pathway is enriched in PmCQ2 infected mice with a deadly outcome (14). Together, these results hint that the PmQ infected chicken attempt to cause cell death of the host, leading to tissue lesions of the lungs.…”
Section: Discussioncontrasting
confidence: 91%
“…The innate immune system is the first line in host defense and protects the host from bacterial infection (25). Previously, we found TLRs and inflammatory cytokines such as IL17, IL6, TNF-α, IFN-γ were significantly upregulated in mouse lungs infected with PmCQ2 (14). Another study also reports that IL6, IL17, and IL22 expression levels were significantly increased in the lungs of chicken challenged with avian P. multocida strain X73, which succumbed to acute infection (26).…”
Section: Discussionmentioning
confidence: 91%
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“…Inflammatory index were scored separately from 0 (lesion absent) to 3 (severe lesion) based on a previous method. 13 RT-PCR Real-time PCR was performed according to our previous study. 6 Primers ( Supplementary Table 1) were selected according to previous references.…”
Section: Tissue Histological Examinationmentioning
confidence: 99%