Transcriptomic signatures associated with autoimmune thyroiditis in papillary thyroid carcinoma and cancer immunotherapy-induced thyroid dysfunction

Li, Yang; Zang, Yue; Fan, Tianda; Li, Zhaochen; Li, Anzi; Lv, Wei; Wang, Qingqing; Li, Qinglan; Li, Yuanyuan; Li, Quan; Sun, Zhen; Teng, Huajing

doi:10.1016/j.csbj.2022.05.019

Cited by 2 publications

(1 citation statement)

References 89 publications

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“…With the change of living environment and the improvement of detection technology, the discovery of thyroid cancer has generally increased [1].Hashimoto's thyroiditis (HT) is an autoimmune disease that usually involves the thyroid gland. Studies have shown that HT may be a precancerous lesion of thyroid cancer, and the incidence of PTC in HT patients has been on the rise in recent years [2].There is an association between thyroid cancer and HT, but the exact mechanism of this relationship is still under debate [3].The pathological mechanism of thyroid changes, including carcinogenic effects, is a complex process involving oxidative stress [4]. Oxidative stress not only participates in tumor formation and development, but also leads to cancer cell death.…”

Section: Introductionmentioning

confidence: 99%

Role of oxidative stress and IL-17 induced inflammatory cytokines in thyroid carcinoma with Hashimoto's thyroiditis

xing,

lu,

Liu

et al. 2023

Preprint

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Objective: To investigate the expression changes and mechanism of oxidative stress and IL-17 induced inflammatory factors in thyroid cancer with Hashimoto's thyroiditis. Method: 40 patients with thyroid cancer accompanied by Hashimoto's thyroiditis were selected as the PTC+HT group, 45 patients with simple thyroid cancer as the PTC group, 42 patients with simple Hashimoto's thyroiditis as the HT group, and 40 healthy individuals as the control group (NC). Evaluate the oxidative stress indicators NO, eNOS, superoxide dismutase (SOD), inflammatory indicators IL-17A, IL-1β and IL-6, thyroid hormones and their antibodies TPOAb and TGAb, as well as related biochemical indicators. Result: The inflammatory and oxidative stress indicators such as IL-17A were significantly increased in the PTC and HT groups compared to the control group, while the PTC+HT group further increased; There was a significant difference in thyroid hormone levels between the PTC+HT group and the HT group compared to the control group (P<0.05); TPOAb, TGAb and NO, eNOS, IL-17A, IL-1 β、IL-6 showed a significant positive correlation and a significant negative correlation with SOD (P<0.05); eNOS, SOD, and IL-17A are risk factors for these three different diseases. Conclusion: IL-17 and its induced inflammatory factors and oxidative stress are highly expressed in PTC+HT, and the synergistic effect between inflammation and oxidative stress leads to thyroid hormone levels and antibody abnormalities in PTC+HT patients. eNOS, SOD, and IL-17A can serve as effective indicators for predicting the occurrence and evaluating changes in PTC+HT disease, and also provide a theoretical basis for future treatment of PTC+HT.

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Section: Introductionmentioning

confidence: 99%

Role of oxidative stress and IL-17 induced inflammatory cytokines in thyroid carcinoma with Hashimoto's thyroiditis

xing,

lu,

Liu

et al. 2023

Preprint

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A comprehensive prediction model for central lymph node metastasis in papillary thyroid carcinoma with Hashimoto’s thyroiditis: BRAF may not be a valuable predictor

Chen,

Zhao,

Zhang

et al. 2024

Front. Endocrinol.

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PurposePapillary thyroid carcinoma (PTC) frequently coexists with Hashimoto’s thyroiditis (HT), which poses challenges in detecting central lymph node metastasis (CLNM) and determining optimal surgical management. Our study aimed to identify the independent predictors for CLNM in PTC patients with HT and develop a comprehensive prediction model for individualized clinical decision-making.Patients and methodsIn this retrospective study, a total of 242 consecutive PTC patients who underwent thyroid surgery and central lymph node dissection between February 2019 and December 2021 were included. 129 patients with HT were enrolled as the case group and 113 patients without HT as control. The results of patients’ general information, laboratory examination, ultrasound features, pathological evaluation, and BRAF mutation were collected. Multivariate logistic regression analysis was used to identify independent predictors, and the prediction model and nomogram were developed for PTC patients with HT. The performance of the model was assessed using the receiver operating characteristic curve, calibration curve, decision curve analysis, and clinical impact curve. In addition, the impact of the factor BRAF mutation was further evaluated.ResultsMultivariate analysis revealed that gender (OR = 8.341, P = 0.013, 95% CI: 1.572, 44.266), maximum diameter (OR = 0.316, P = 0.029, 95% CI: 0.113, 0.888), multifocality (OR = 3.238, P = 0.010, 95% CI: 1.319, 7.948), margin (OR = 2.750, P = 0.046, 95% CI: 1.020, 7.416), and thyrotropin receptor antibody (TR-Ab) (OR = 0.054, P = 0.003, 95% CI: 0.008, 0.374) were identified as independent predictors for CLNM in PTC patients with HT. The area under the curve of the model was 0.82, with accuracy, sensitivity, and specificity of 77.5%, 80.3% and 75.0%, respectively. Meanwhile, the model showed satisfactory performance in the internal validation. Moreover, the results revealed that BRAF mutation cannot further improve the efficacy of the prediction model.ConclusionMale, maximum diameter > 10mm, multifocal tumors, irregular margin, and lower TR-Ab level have significant predictive value for CLNM in PTC patients with HT. Meanwhile, BRAF mutation may not have a valuable predictive role for CLNM in these cases. The nomogram constructed offers a convenient and valuable tool for clinicians to determine surgical decision and prognostication for patients.

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Transcriptomic signatures associated with autoimmune thyroiditis in papillary thyroid carcinoma and cancer immunotherapy-induced thyroid dysfunction

Cited by 2 publications

References 89 publications

Role of oxidative stress and IL-17 induced inflammatory cytokines in thyroid carcinoma with Hashimoto's thyroiditis

Role of oxidative stress and IL-17 induced inflammatory cytokines in thyroid carcinoma with Hashimoto's thyroiditis

A comprehensive prediction model for central lymph node metastasis in papillary thyroid carcinoma with Hashimoto’s thyroiditis: BRAF may not be a valuable predictor

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