Transcriptomics Provides Novel Insights into the Regulatory Mechanism of lncRNA HIF1A-AS1 on Vascular Smooth Muscle Cells
Jin Yang,
Zhiqiang Gong,
Junjie Dong
et al.
Abstract:Introduction
Thoracic aortic aneurysm is a potentially fatal disease with a strong genetic
contribution. The dysfunction of vascular smooth muscle cells (VSMCs)
contributes to the formation of this aneurysm. Although previous studies
suggested that long non-coding ribonucleic acid (RNA) hypoxia inducible
factor 1 α-antisense RNA 1 (HIF1A-AS1) exerted a vital role in the
progression and pathogenesis of thoracic aortic aneurysm, we managed to find
a new regulatory mechanism of HIF1A-AS1 in VSMCs via… Show more
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