Transcutaneous immunization with Intercell's vaccine delivery system

Seid, Robert C.; Look, Jee Loon; Ruiz, Christian; Frolov, Vladimir; Flyer, David C.; Schafer, Jason J.; Ellingsworth, Larry

doi:10.1016/j.vaccine.2011.09.113

Cited by 18 publications

(9 citation statements)

References 33 publications

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“…A lipid-based vaccine formulation, such as lipid C-based vaccines[149] and emulsion-based vaccines[150] would be ideal due to their compatibility with different forms of vaccines. Several methods have been shown effective, including partial removal of the SC by mild abrasion[151], tape-stripping[152], or device-facilitated creation of aqueous micropores (laser microporation)[153]. A transcutaneous patch could also be designed to contain only a vaccine adjuvant for efficacy enhancement for an injectable vaccine[151].…”

Section: Introductionmentioning

confidence: 99%

“…Several methods have been shown effective, including partial removal of the SC by mild abrasion[151], tape-stripping[152], or device-facilitated creation of aqueous micropores (laser microporation)[153]. A transcutaneous patch could also be designed to contain only a vaccine adjuvant for efficacy enhancement for an injectable vaccine[151]. …”

Section: Introductionmentioning

confidence: 99%

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Effect of vaccine administration modality on immunogenicity and efficacy

Zhang

Wang

2015

Expert Review of Vaccines

197

149

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Summary The many factors impacting the efficacy of a vaccine can be broadly divided into three categories: (1) features of the vaccine itself, including immunogen design, vaccine type, formulation, adjuvant, and dosing; (2) individual variations among vaccine recipients; and (3) vaccine administration-related parameters. While much literature exists related to vaccines, and recently systems biology has started to dissect the impact of individual subject variation on vaccine efficacy, few studies have focused on the role of vaccine administration-related parameters on vaccine efficacy. Parenteral and mucosal vaccinations are traditional approaches for licensed vaccines; novel vaccine delivery approaches, including needless injection and adjuvant formulations, are being developed to further improve vaccine safety and efficacy. This review provides a brief summary of vaccine administration-related factors, including vaccination approach, delivery route, and method of administration, to gain a better understanding of their potential impact on the safety and immunogenicity of candidate vaccines.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of vaccine administration modality on immunogenicity and efficacy

Zhang

Wang

2015

Expert Review of Vaccines

197

149

View full text Add to dashboard Cite

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“…Ablation of stratum corneum has been shown to induce delivery of vaccines into skin. Abrasion of stratum corneum using simpler means, for example, sandpaper is often performed before the placement of topical vaccines in experimental and clinical systems 99) . Devices have also been developed to obtain controlled disruption of stratum corneum using abrasives devices 100) .…”

Section: Removal Poration and Ablation Of Stratum Corneummentioning

confidence: 99%

Mechanical Disruption of Skin Barrier for Vaccine Delivery

Mitragotri¹

2012

Official Journal of the Japan Society of Drug Delivery System

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Delivering vaccines into skin offers an appealing alternative to needle-based administration for immunization. Besides the benefit of directly delivering vaccines into immunologically competent skin, cutaneous immunization provides the benefits of patient compliance and dose sparing. Vaccine delivery into skin, however, is limited by the barrier of stratum corneum, the outermost layer of skin. A variety of technologies have been developed to permeabilize the stratum corneum to enhance vaccine entry into skin. This review provides a summary of some of these technologies that are based on mechanical disruption of stratum corneum. These include liquid jet injectors, powder injectors, ultrasound, microneedles, abrasive devices, thermal ablation and lasers. An overview of the principles of these technologies, their ability to deliver vaccines and experience in clinical applications is discussed.

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“…In order to answer this question functionalization of CNTs with gallic acid, a compound that is not used as a MALDI matrix but has a similar acid dissociation constant to sinapinic acid, was carried out. The usefulness of every assisting surface was investigated with three chemically different substances that can be found in biological samples: folic acid, which has many functions in living organisms, for example it is needed to synthesize and repair DNA; vancomycin, an antibiotic which is used in treatment of infections caused by Gram‐positive bacteria; Triton ® X‐100, which apart from being used as a surfactant in cleaning agents is also an ingredient of different types of vaccines …”

mentioning

confidence: 99%

“…The usefulness of every assisting surface was investigated with three chemically different substances that can be found in biological samples: folic acid, which has many functions in living organisms, for example it is needed to synthesize and repair DNA; vancomycin, an antibiotic which is used in treatment of infections caused by Gram-positive bacteria; Triton ® X-100, which apart from being used as a surfactant in cleaning agents is also an ingredient of different types of vaccines. [40] EXPERIMENTAL Chemicals and materials Folic acid, vancomycin hydrochloride, Triton ® X-100, gallic acid and sinapinic acid were obtained from Sigma-Aldrich (St. Louis, MO, USA). CNTs (multi-walled nanotubes) with average diameter of 10-20 nm and average length 10-30 μm, denoted as CNT, hydroxylated CNTs (multi-walled nanotubes, -OH functionalized, >95% purity) with average diameter of 10-20 nm and average length 10-30 μm, denoted as CNT-OH, carboxylated CNTs (multi-walled nanotubes, -COOH functionalized, >95% purity) with average diameter of 10-20 nm and average length 10-30 μm, denoted as CNT-COOH, were obtained from Nanostructured & Amorphous Materials, Inc. (Houston, TX, USA).…”

mentioning

confidence: 99%