Transcutaneous Neuromodulation improved inflammation and sympathovagal ratio in patients with primary biliary ssscholangitis and inadequate response to Ursodeoxycholic acid: a pilot study

Yang, Hui; Yang, Hang; Wang, Lixia; Shi, Honggang; Xue, Liyan; Chang, Qingyong; Chen, Jiande D.Z.; Duan, Zhijun

doi:10.1186/s12906-020-03036-w

Cited by 5 publications

(3 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Colitis causes gut dysbiosis, increase bacterial translocation to the liver leading to hepatic damage in mice with DSS, and is associated with an increase in the level of hepatic LPS ( Cheng et al, 2018 ; Svegliati-Baroni et al, 2020 ). The inflammatory factors secreted by liver can enter intestine, and aggravate the damage of intestinal lining and disrupt microbiota through the bile secretion into the intestinal lumen ( Yang et al, 2020 ). Several shreds of evidence that liver injury diseases are causally associated with impaired intestinal permeability.…”

Section: Discussionmentioning

confidence: 99%

High-fat diet combined with dextran sulfate sodium failed to induce a more serious NASH phenotype than high-fat diet alone

et al. 2022

View full text Add to dashboard Cite

Background and Aims: Animal models are essential tools to investigate the pathogenesis of diseases. Disruption in the intestinal epithelial barrier and gut vascular barrier is an early event in the development of non-alcoholic fatty liver disease (NAFLD). Intestinal epithelial barrier can be destroyed by dextran sulfate sodium (DSS) oral administration. High fat diet (HFD)-induced non-alcoholic steatohepatitis (NASH) rat model has been widely used. Recently, the combination of HFD with DSS induced NASH model has also been reported. The present study aimed to evaluate whether this composite NASH animal model is more ideal than that induced by HFD alone.Methods: Rats were divided into control, HFD and HFD combined with DSS (DSS + HFD) groups. They were fed with routine diet, high-fat diet, and HFD combined with DSS drinking, respectively, for 22 weeks. Histopathological analysis (HE staining, Oil-Red O staining, Masson staining), lipid parameters testing (TG, TC, GLU, NEFA, TRIG, LDL, HDL), testing on indicators of inflammation (TNF-α, ALT, AST, ALP, LDH) and oxidative stress (MDA, SOD, CAT) were performed.Results: Rats in HFD and DSS + HFD group displayed increase in the body weight, liver weight, lipids accumulation and the levels of TNF-α, ALT, AST, ALP, MDA in serum and liver accompanied with impaired glucose tolerance, obvious hepatitis, and decreased levels of SOD and CAT in serum and liver compared to those in control group. Moreover, in the DSS + HFD group, but not in the HFD group, proliferation of fibrous tissue in the portal area and the hepatic lobules was found.Conclusion: The addition of DSS on high-fat diet did not exacerbate lipid accumulation and inflammation, but induced NASH-related liver fibrosis.

show abstract

Section: Discussionmentioning

confidence: 99%

High-fat diet combined with dextran sulfate sodium failed to induce a more serious NASH phenotype than high-fat diet alone

et al. 2022

View full text Add to dashboard Cite

show abstract

“…According to the theory of “Xingnao Kaiqiao Acupuncture” in traditional Chinese medicine [ 15 ], three acupuncture points were selected as the target points: bilateral Neiguan [ 16 ] (PC6, on the palmar side of the forearm, 3 cm proximal to the transverse carpal crease, between the palmaris longus tendon and the radial flexor carpi tendon), Yintang [ 17 ] (GV29 ], on the forehead of the human body, between the two eyebrows) and bilateral Zusanli [ 18 ] (ST36, 3 inches below the outer knee). Patients in the TEAS group received perioperative TEAS by two experienced researchers and the treatment time was 30 min before the induction of anesthesia until the end of the surgery, 1 day before operation, and from the first day to the third day after the operation.…”

Section: Methodsmentioning

confidence: 99%

Transcutaneous electrical acupoint stimulation for postoperative cognitive dysfunction in geriatric patients with gastrointestinal tumor: a randomized controlled trial

Fang

Yuan

et al. 2021

Trials

View full text Add to dashboard Cite

Background This study aimed to evaluate the effect of perioperative transcutaneous electrical acupoint stimulation (TEAS) on postoperative cognitive dysfunction (POCD) in older patients who were diagnosed with gastrointestinal tumor and received radical resection of gastrointestinal tumors under general anesthesia. Methods A total of 68 patients who received radical resection of gastrointestinal tumors under general anesthesia were randomly divided into two groups. TEAS group patients received TEAS treatment. The treatment time was 30 min before the induction of anesthesia until the end of the surgery, 1 day before operation and from the first day to the third day after the operation. Except on the day of surgery, we treated the patients for 30 min once a day. In the sham TEAS group, the electronic stimulation was not applied and the treatment was the same as the TEAS group. The primary outcome was perioperative cognition evaluated by the Mini-Mental State Examination (MMSE) and secondary outcomes were the perioperative level of interleukin-6 (IL-6), S100 calcium-binding protein β (S100β), and C-reactive protein (CRP). Results The postoperative score of MMSE, orientation, memory, and short-term recall in the sham TEAS group was significantly lower than the preoperative and TEAS group (P < 0.05). The incidence of POCD in the TEAS group (21.88%) was lower than those in the sham TEAS group (40.63%). S100β, IL-6, and CRP in the TEAS group were significantly lower than those in the sham TEAS group on the third day after the operation (P< 0.05). Postoperative S100β, IL-6, and CRP in two groups were significantly higher than those before operation except for S100β on the third day after the operation in the TEAS group (P < 0.05). Conclusions Perioperative TEAS treatment reduced the postoperative inflammatory response and increased the postoperative cognitive function score and decrease the incidence of POCD in geriatric patients with gastrointestinal tumor. Trial registration ClinicalTrials.gov NCT04606888. Registered on 27 October 2020. https://register.clinicaltrials.gov.

show abstract

“…Therefore, therapeutic manipulation of the gut–brain axis has become of interest in this group of patients. Recently, it has been shown that neuromodulation via a tibial nerve acupuncture point increased parasympathetic drive and reduced Il6 and gamma-glutaminetransferase (GGT) levels in a small group of patients with PBC who previously had an inadequate response to ursodeoxycholic acid [8 ▪ ]. This pilot study holds promise for the manipulation of the gut–brain axis as a novel therapeutic strategy for this difficult to treat condition.…”

Section: Systemic Effects Of the Gut–brain Axis Via The Cholinergic A...mentioning

confidence: 99%

The bi-directional role of the gut–brain axis in inflammatory and other gastrointestinal diseases

Mogilevski

2021

Current Opinion in Gastroenterology

View full text Add to dashboard Cite

Purpose of review There is a growing body of evidence implicating the role of the gut–brain axis in a multitude of inflammatory and non-inflammatory gastrointestinal disorders. The interaction between the gut and the brain is bidirectional and its therapeutic manipulation is gaining traction as the new frontier in the management of gastrointestinal disorders. This review summarizes the recent literature on this subject and serves as a reference for future research directions. Recent findings Recent studies have shown that the gut–brain axis, through its main communicator – the vagal nerve – plays a multimodal role in manipulating gastrointestinal physiology. This is evident systemically via the cholinergic anti-inflammatory pathway, through its effect on intestinal barrier function and also locally on intestinal epithelial and immune cells. Vagal nerve stimulation and faecal microbiota transplantation are two ways by which therapeutic manipulation has been attempted with success. Summary There has been exceptional progress in our understanding of the gut–brain axis in recent literature. Its role in the modulation of a multitude of gastrointestinal disorders is becoming clear. Preclinical findings are sufficient for this research to proceed to clinical trials in order to harness its clinical therapeutic potential for the care of patients.

show abstract

Transcutaneous Neuromodulation improved inflammation and sympathovagal ratio in patients with primary biliary ssscholangitis and inadequate response to Ursodeoxycholic acid: a pilot study

Cited by 5 publications

References 54 publications

High-fat diet combined with dextran sulfate sodium failed to induce a more serious NASH phenotype than high-fat diet alone

High-fat diet combined with dextran sulfate sodium failed to induce a more serious NASH phenotype than high-fat diet alone

Transcutaneous electrical acupoint stimulation for postoperative cognitive dysfunction in geriatric patients with gastrointestinal tumor: a randomized controlled trial

The bi-directional role of the gut–brain axis in inflammatory and other gastrointestinal diseases

Contact Info

Product

Resources

About