Transcutol containing vesicles for topical delivery of minoxidil

Abstract

The aim of this work was to evaluate the ability of Transcutol (Trc) to produce elastic vesicles with soy lecithin (SL) and study the influence of the obtained vesicles on in vitro (trans)dermal delivery of minoxidil. To this purpose, so-called penetration enhancer-containing vesicles (PEVs) were prepared using Trc aqueous solutions (5-10-20-30% v/v) as hydrophilic phase. SL liposomes, without Trc, were used as control. Prepared formulations were characterized in terms of size distribution, morphology, zeta potential, deformability, and rheological behavior. The influence of the obtained PEVs on (trans)dermal delivery of minoxidil was studied by in vitro diffusion experiments through pig skin. Results showed that all prepared PEVs were able to give good entrapment efficiency (E%≈67) similar to that of conventional liposomes. Trc-containing PEVs showed to be more deformable than liposomes only when minoxidil was loaded in 5 and 10% Trc-containing vesicles. Rheological studies showed that PEVs have higher fluidity than conventional liposomes. All PEVs showed a higher stability than liposomes as shown by studying zeta potential and size distribution during three months. Results of in vitro diffusion experiments showed that Trc-containing PEVs are able to deliver minoxidil to deep skin layers without any transdermal permeation.

Follicular delivery of spironolactone via nanostructured lipid carriers for management of alopecia

“…18,19 Transcutol ® , being biocompatible with the skin, was incorporated into the NLCs as a penetration enhancer. 20 The composition of the prepared SL-NLCs is presented in Table 2.…”

Penetration enhancer containing vesicles as carriers for dermal delivery of tretinoin

“…In previous studies, we introduced the acronym PEVs to identify the penetration enhancer containing vesicles as carriers for dermal delivery of minoxidil and diclofenac Mura et al, 2009Mura et al, , 2011. These vesicles have shown to possess the advantage to combine liposome potential as carriers and PE ability to modify the order of stratum corneum (SC) packing (Mura et al, , 2011, thus promoting skin delivery. Moreover, during last years the benefits of trans-retinoic acid (TRA) incorporation in liposomes and niosomes on its dermal delivery have also been extensively studied (Trapasso et al, 2009).…”

“…Recently, different penetration enhancer (PE) molecules have been tested as "edge activator" in the formulation of new deformable vesicles by several authors (Verma, 2002;El Maghraby et al, 2004;Elsayed et al, 2007;Dragicevic-Curic et al, 2008;Manconi et al, 2009). In previous studies, we introduced the acronym PEVs to identify the penetration enhancer containing vesicles as carriers for dermal delivery of minoxidil and diclofenac Mura et al, 2009Mura et al, , 2011. These vesicles have shown to possess the advantage to combine liposome potential as carriers and PE ability to modify the order of stratum corneum (SC) packing (Mura et al, , 2011, thus promoting skin delivery.…”

Squarticles as a Lipid Nanocarrier for Delivering Diphencyprone and Minoxidil to Hair Follicles and Human Dermal Papilla Cells

“…The loading capacity of >60% for minoxidil was surprising. Mura et al (23) suggest that minoxidil can be largely incorporated in phospholipid bilayers of liposomes. SPC in the interface of squarticles left spaces to accommodate minoxidil molecules.…”