Transdermal absorption enhancing effect of the essential oil of<i>Rosmarinus officinalis</i>on percutaneous absorption of Na diclofenac from topical gel

Âkbari, Jafar; Saeedi, Majid; Farzin, Davood; Morteza‐Semnani, Katayoun; Esmaili, Zahra

doi:10.3109/13880209.2014.984855

Cited by 41 publications

(24 citation statements)

References 30 publications

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“…Moreover, essential oils (EOs) and their volatile constituents have also been identified as one promising group of candidates to be employed as clinically acceptable PEs. Until now, EOs have been shown to be successful in delivering a range of different drugs across the skin, including vitamins (Valgimigli et al 2012), estradiol (Monti et al 2002), labetolol hydrochloride (Jain et al 2008), trazodone hydrochloride (Das et al 2006), tetramethylpyrazine (Shen et al 2013), carvedilol (Amin et al 2008), 5-fluorouracil (5-FU) (Lan et al 2014a), flurbiprofen (Zhang et al 2006;Charoo et al 2008), diclofenac sodium (Akbari et al 2015), indomethacin (Lan et al 2014a) and ibuprofen (Luo et al 2007;Shen et al 2007;Khan et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Development of essential oils as skin permeation enhancers: penetration enhancement effect and mechanism of action

Jiang

Zhang

et al. 2017

Pharmaceutical Biology

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Section: Introductionmentioning

confidence: 99%

Development of essential oils as skin permeation enhancers: penetration enhancement effect and mechanism of action

Jiang

Zhang

et al. 2017

Pharmaceutical Biology

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“…Terpenes are an effective class of permeation enhancers obtained from natural sources (Akbari et al 2015). Further, quite a few terpenes are included in the list of Generally Recognized As Safe (GRAS) agents issued by the US Food and Drug Administration (US FDA) (Aqil et al 2007;Sapra et al 2008).…”

Section: Introductionmentioning

confidence: 99%

The application of anethole, menthone, and eugenol in transdermal penetration of valsartan: Enhancement and mechanistic investigation

Ahad

Aqil

Ali

2015

Pharmaceutical Biology

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Context:The main barrier for transdermal delivery is the obstacle property of the stratum corneum. Many types of chemical penetration enhancers have been used to breach the skin barrier; among the penetration enhancers, terpenes are found as the most highly advanced, safe, and proven category. Objective: In the present investigation, the terpenes anethole, menthone, and eugenol were used to enhance the permeation of valsartan through rat skin in vitro and their enhancement mechanism was investigated. Materials and methods: Skin permeation studies of valsartan across rat skin in the absence and the presence of terpenes at 1% w/v, 3% w/v, and 5% w/v in vehicle were carried out using the transdermal diffusion cell sampling system across rat skin and samples were withdrawn from the receptor compartment at 1, 2, 3, 4, 6, 8, 10, 12, and 24 h and analysed for drug content by the HPLC method. The mechanism of skin permeation enhancement of valsartan by terpenes treatment was evaluated by Fourier transform infrared spectroscopy (FTIR) analysis and differential scanning calorimetry (DSC). Results: All the investigated terpenes provided a significant (p50.01) enhancement in the valsartan flux at a concentration of 1%, and less so at 3% and 5%. The effectiveness of terpenes at 1% concentration was in the following order: anethole4menthone4eugenol with 4.4-, 4.0-, and 3.0-fold enhancement ratio over control, respectively. DSC study showed that the treatment of stratum corneum with anethole shifted endotherm down to lower melting point while FTIR studies revealed that anethole produced maximum decrease in peak height and area than other two terpenes. Conclusion: The investigated terpenes can be successfully used as potential enhancers for the enhancement of skin permeation of lipophilic drug. ARTICLE HISTORY

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“…Therefore, it demonstrated greater sensitivity to these essences. This is probably due to the differences in the strength of the cell wall of gram-negative and gram-positive bacteria and lack of membrane in gram-positive bacteria (24). It is important to know that the compositions in plant extracts may introduce the most effective agent in the extract.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the reaction of bacterial strains to antibiotics, tests showed that all strains reacted similarly to a special antibiotic; this is indicative of low genetic diversity of strains in populations under study. However, the strains responded differently to various types of antibiotics and this is due to the type and mode of action of antibiotics on specific loca- (24). The existence of free radicals in the extract of this plant could also be effective in inhibiting bacteria and the ethyl acetate compound in the extract could create maximum inhibitory effect (25).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Antimicrobial Activity of Essential Oil of Eshvark (Rhazya stricta) Against Two Strains of Staphylococcus aureus and Listeria monocytogenes

et al. 2017

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Background: Many diseases are often caused by bacteria, including those caused by Staphylococcus aureus and Listeria monocytogenes. Staphylococcus aureus has a hospital infection source and can cause simple skin diseases such as rashes, as well as more severe diseases, such as pneumonia and meningitis. Listeria monocytogenes has an environmental source, such as water, soil and food, and attacks the central nervous system and causes neurological symptoms, even leading to death. Objectives: This study aimed at evaluating antimicrobial effects of ethanol extract and essential oil Eshvark against clinical isolates of S. aureus and L. monocytogenes, which are resistant to antibiotics. Methods: Different strains of S. aureus bacteria were isolated from Bu-Ali hospital of Zahedan, and standard strains of L. monocytogenes (PTCC 1630) were provided as a lyophilized vial in Iranian collection center of fungus and bacteria (Iranian research organization for Science and industry). In this study, the essential oil of Razya stritca was obtained by Clevenger. Then the minimum inhibitory concentrations were investigated to characterize the antibacterial activities of this essential oil. Results: These tests showed that the approximate minimum inhibitory concentration was at concentrations of 5 and 10 mg per milliliter, and the amount of inhibitory concentration for S. aureus was 25/83 and 6/17 while this amount for L. monocytogenes was 5/53 and 1/7, and the minimum bactericidal concentration (MBC) was also at concentrations of 5 and 10 mg per milliliter. Conclusions: This study confirmed the antimicrobial potential of investigated plants and their usefulness in treatment of resistant isolates of S. aureus and L. monocytogenes.

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Transdermal absorption enhancing effect of the essential oil ofRosmarinus officinalison percutaneous absorption of Na diclofenac from topical gel

Abstract: This study proved the enhancing effect of 0.5 and 1% of rosemary essential oil on diclofenac percutaneous absorption.

Cited by 41 publications

References 30 publications

Development of essential oils as skin permeation enhancers: penetration enhancement effect and mechanism of action

Development of essential oils as skin permeation enhancers: penetration enhancement effect and mechanism of action

The application of anethole, menthone, and eugenol in transdermal penetration of valsartan: Enhancement and mechanistic investigation

Evaluation of Antimicrobial Activity of Essential Oil of Eshvark (Rhazya stricta) Against Two Strains of Staphylococcus aureus and Listeria monocytogenes

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