Transdermal delivery of mixnoxidil with block copolymer nanoparticles

Shim, Jongwon; Kang, Hyung Seok; Park, Won Seok; Han, Sang Hun; Kim, Junoh; Chang, Ih-Seop

doi:10.1016/j.jconrel.2004.03.028

Cited by 154 publications

(121 citation statements)

References 13 publications

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“…Particulate formulation has been shown to enhance both the uptake of drugs into skin in general [4,5] but also specifically into hair follicles in a size-dependent manner [6,7]. Some of the polymeric particles that are reported in the literature contain esters or are ester-based (e.g., PCL [8], PLA [6], PLGA [7]) and thus are principally biodegradable.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Core–Multishell Nanocarriers: Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus

et al. 2017

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Abstract:We here present the synthesis and characterization of a set of biodegradable core-multishell (CMS) nanocarriers. The CMS nanocarrier structure consists of hyperbranched polyglycerol (hPG) as core material, a hydrophobic (12,15,18,19, and 36 C-atoms) inner and a polyethylene glycol monomethyl ether (mPEG) outer shell that were conjugated by ester bonds only to reduce the toxicity of metabolites. The loading capacities (LC) of the drugs, dexamethasone and tacrolimus, and the aggregate formation, phase transitions, and degradation kinetics were determined. The intermediate inner shell length (C15) system had the best overall performance with good LCs for both drugs as well as a promising degradation and release kinetics, which are of interest for dermal delivery.

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Section: Introductionmentioning

confidence: 99%

Biodegradable Core–Multishell Nanocarriers: Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus

et al. 2017

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“…NPs of this size range have been reported to exhibit penetration into epidermis layer. 15,44 Zeta potential of optimized batch was found to be excellent (−31 mV), indicating good electrostatic stabilization. 45 Optimized batch showed entrapment efficiency of 12.27%, which was highest among the batches prepared.…”

Section: Morin-excipient Compatibility Studiesmentioning

confidence: 94%

Development and evaluation of sunscreen creams containing morin-encapsulated nanoparticles for enhanced UV radiation protection and antioxidant activity

Shetty

Venuvanka

Jagani

et al. 2015

IJN

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The objective of present work was to develop novel sunscreen creams containing polymeric nanoparticles (NPs) of morin. Polymeric NPs containing morin were prepared and optimized. The creams containing morin NPs were also prepared and evaluated. Optimized NPs exhibited particle size of 90.6 nm and zeta potential of −31 mV. The entrapment efficiency of morin, within the polymeric NPs, was found to be low (12.27%). Fourier transformed infrared spectroscopy and differential scanning calorimetry studies revealed no interaction between morin and excipients. Transmission electron microscopy and atomic force microscopy revealed that the NPs were spherical in shape with approximately 100 nm diameter. Optimized NPs showed excellent in vitro free radical scavenging activity. Skin permeation and deposition of morin from its NPs was higher than its plain form. Different sunscreen creams (SC1–SC8) were formulated by incorporating morin NPs along with nano zinc oxide and nano titanium dioxide. SC5 and SC8 creams showed excellent sun protection factor values (≈40). In vitro and in vivo skin permeation studies of sunscreen creams containing morin NPs indicated excellent deposition of morin within the skin. Morin NPs and optimized cream formulations (SC5 and SC8) did not exhibit cytotoxicity in Vero and HaCaT cells. Optimized sunscreen creams showed excellent dermal safety. SC5 and SC8 creams demonstrated exceptional in vivo antioxidant effect (estimation of catalase, superoxide dismutase, and glutathione) in UV radiation-exposed rats. The optimized sunscreen creams confirmed outstanding UV radiation protection as well as antioxidant properties.

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“…This section focuses on in vivo kinetic properties of ENMs, addressing processes related to circulation, distribution, degradation, and excretion. There are different routes of administration including pulmonal, 114 dermal, 115,116 oral, 117,118 and IV routes. 119 However, this review will focus only on the IV route in healthy subjects.…”

Section: The Biological Fate Of Enmsmentioning

confidence: 99%