Transdermal delivery via medical device technologies

Shukla, Shubhangi; Huston, Ryan H.; Cox, Blake; Satoskar, Abhay R.; Narayan, Roger J.

doi:10.1080/17425247.2022.2135503

Cited by 7 publications

(3 citation statements)

References 127 publications

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“…Ex vivo ISF Extraction and Testing of Biomarkers in Biofluid: The oblique design of an individual needle in an MN array (shown in Figure 3) combined with pressure-driven drag facilitated the successful withdrawal of ISF from porcine skin. The MN [78,79] -attached suction holder was pressed against the fresh porcine skin for %8-10 min. Similar to a disposable medical syringe (5 mL), a low-pressure area of À74 kPa (measured with digital manometer) was created through the suction setup (shown in Figure S10, Supporting Information).…”

Section: Methodsmentioning

confidence: 99%

Microneedle‐Integrated Device for Transdermal Sampling and Analyses of Targeted Biomarkers

et al. 2023

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Currently available point‐of‐care systems for body fluid collection exhibit poor integration with sensors. Herein, the design of a disposable device for interstitial fluid (ISF) extraction as well as glucose, lactate, and potassium ion (K+) monitoring is reported on. It is minimally invasive and appropriate for single use, minimizing the risk of infection to the user. This microscale device contains a 3D‐printed cap‐like structure with a four‐by‐four microneedle (MN) array, bioreceptor‐modified carbon fiber (CF)‐sensing surface, and negative pressure convection technology. These features are incorporated within a compact, self‐contained, and manually operated microscale device, which is capable of withdrawing ≈3.0 μL of ISF from the skin. MN arrays applied with an upward driving force may increase the ISF flow rate. Moreover, functionalized CF working electrodes (WE1, WE2, WE3) are shown to selectively detect lactate, glucose, and K+ with high sensitivities of 0.258, 0.549, and 0.657 μA μm−1 cm−2 and low detection limits of 0.01, 0.080, 0.05 μm, respectively. Ex vivo testing on porcine skin is used to detect the ISF levels of the biomarkers. The microscale device can be a replacement for current point‐of‐care diagnostic approaches.

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Section: Methodsmentioning

confidence: 99%

Microneedle‐Integrated Device for Transdermal Sampling and Analyses of Targeted Biomarkers

et al. 2023

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“…Linear structures such as nanorods, nanowires, and nanotubes with diameters ranging between 1 and 100 nm are classified as one-dimensional nanomaterials. Carbon nanotubes (CNTs) have gained much attention as drug carrier platforms [41] , [42] , as their large volume supports the spontaneous encapsulation and affluent cell uptake without triggering immunogenic responses ( Fig. 1 A).…”

Section: One Dimensional Nanocarriersmentioning

confidence: 99%

Computational approaches to delivery of anticancer drugs with multidimensional nanomaterials

Shukla

Jakowski

Kadian

et al. 2023

Computational and Structural Biotechnology Journal

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“…Among the various external parameters, pH is considered a significant factor due to variable pH conditions in the physiological system, which can facilitate drug release. Several pH-sensitive polymeric hydrogels with pH labile functional groups (e.g., hydrazone/amine/carboxylic/sulfonyl) have been prepared as oral dosage forms for drug release in the gastrointestinal tract. ,,− Acidic polyelectrolytes such as polymethyl acrylic ethylene glycol, cationic polymers such as aminoalkyl methacrylate copolymer (Eudragit E), and polyvinylacetal diethylaminoacetate (AEA) are sensitive to acidic pH; anionic polyelectrolytes such as poly(methacrylic acid–methyl methacrylate) (e.g., Eudragit L, S, and F) respond favorably to a basic medium. , These excipients also perform a taste-masking function in drug formulations. ,− …”

Section: Introductionmentioning

confidence: 99%

Development of Drug-Loaded PCL@MOF Film Enclosed in a Photo Polymeric Container for Sustained Release

Shukla,

Joshi,

Kadian

et al. 2024

ACS Appl. Bio Mater.

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The programmed fabrication of oral dosage forms is associated with several challenges such as controlled loading and disintegration. To optimize the drug payload, excipient breakdown, and site-specific sustained release of hydrophobic drug (sulfamethoxazole, SM), we propose the development of acrylate polymer tablets enclosed with drug-loaded polycaprolactone (PCL) films. The active pharmaceutical ingredient (API) is physisorbed into the porous iron (Fe)-based metal−organic framework (MOF) and later converted to tangible PCL films, which, upon folding, are incorporated into the acrylate polymer matrices (P1/P2/P3). X-ray powder diffraction (XRPD) analysis and scanning electron microscopy (SEM) micrographs confirmed the stability and homogeneous distribution of MOF within the 50 μm thick film. Adsorption−desorption measurements at ambient temperatures confirmed the decrease in the BET surface area of PCL films by 40%, which was ∼3.01 m/g, and pore volume from 30 to 9 nm. The decrease in adsorption and surface parameters could confirm the gradual accessibility of SM molecules once exposed to a degrading environment. Fourier transform infrared (FTIR) analyses of in vitro dissolution confirmed the presence of the drug in the MOF-PCL film-enclosed tablets and concluded the cumulative SM release at pH ∼ 8.

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Transdermal delivery via medical device technologies

Cited by 7 publications

References 127 publications

Microneedle‐Integrated Device for Transdermal Sampling and Analyses of Targeted Biomarkers

Microneedle‐Integrated Device for Transdermal Sampling and Analyses of Targeted Biomarkers

Computational approaches to delivery of anticancer drugs with multidimensional nanomaterials

Development of Drug-Loaded PCL@MOF Film Enclosed in a Photo Polymeric Container for Sustained Release

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