Transdermal ethosomal gel nanocarriers; a promising strategy for enhancement of anti-hypertensive effect of carvedilol

Ibrahim, Tarek; Abdallah, Marwa H.; El-Megrab, Nagia A.; El-Nahas, Hanan M.

doi:10.1080/08982104.2018.1529793

Cited by 44 publications

(19 citation statements)

References 40 publications

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“…The enhanced permeation properties with the ethosomes can be related to the synergistic interplay of ethanol as penetration enhance with skin lipids and vesicles. Ethanol fluidizes both the vesicular and SC lipids providing greater flexibility and enhanced permeation while phospholipids aid in vesicles mixing with the skin lipids developing openings in the SC for ease of drug penetration (Ibrahim et al 2019). Chin and Goldstein (1997) reported that blending of intercellular layers SC lipids with vesicles lipids further boosts the skin permeability of drugs, which further supports the outcomes of our permeation study.…”

Section: Ex-vivo Permeation Studies and Drug Retaining On Skin Surfacesupporting

confidence: 85%

Ethosomes-based gel formulation of karanjin for treatment of acne vulgaris: in vitro investigations and preclinical assessment

et al. 2021

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The aim of the present study was to develop and characterize karanjin-loaded ethosomes-based gel formulation for enhanced topical delivery and effective therapy of skin acne. Karanjin-loaded ethosomes (K-ETH) presented a nanometric size of 140.87 ± 2.35 nm, entrapment of 71.41 ± 2.74% and enhanced permeation with 1.9 times increase in the flux and 2.4 times higher skin deposition compared to the hydro-ethanolic solution of karanjin. The DSC analysis confirmed successful entrapment of the karanjin within the ethosomes. The developed ethosomes were incorporated in the carbopol gel for adequate application on the skin surface. The ethosomal gel (K-EGF) also exhibited greater penetration in the rat skin as revealed by CLSM. The optimized K-EGF formulation was non-irritant to the skin as evident by Draize score test and histopathological examination. The highest zone of inhibition, 30.0 ± 1.52 mm and 36.22 ± 0.57 mm was produced by the K-EGF against Propionibacterium acnes and Staphylococcus epidermidis, respectively, indicating substantial antibacterial properties of the K-EGF. DPPH assay indicated its potent antioxidant effects. Substantial anti-inflammatory effects in the carrageenan-induced edema in the rat paw were evident with inhibition of rat paw edema by 66.66% and 70.37% upon application of K-EGF and standard anti-inflammatory agent, respectively. Anti-acne effects were also evident with K-EGF treatment with significant decrease in number and size of sebaceous gland units in dermis. Overall, the above findings vouch for a therapeutic opportunity to improve topical delivery of karanjin in acne treatment employing ethosomal gels as the promising carrier system.

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Section: Ex-vivo Permeation Studies and Drug Retaining On Skin Surfacesupporting

confidence: 85%

Ethosomes-based gel formulation of karanjin for treatment of acne vulgaris: in vitro investigations and preclinical assessment

et al. 2021

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“…The pH value of the topical formulation is very critical parameter to ensure the safety of the preparation. This evaluation was carried out using Standardized pH meter (MW802, Milwaukee Instruments, Szeged, Hungary) [ 53 ].…”

Section: Methodsmentioning

confidence: 99%

Quality by Design for Optimizing a Novel Liposomal Jojoba Oil-Based Emulgel to Ameliorate the Anti-Inflammatory Effect of Brucine

Abdallah

Elsewedy

Lila

et al. 2021

Gels

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One of the recent advancements in research is the application of natural products in developing newly effective formulations that have few drawbacks and that boost therapeutic effects. The goal of the current exploration is to investigate the effect of jojoba oil in augmenting the anti-inflammatory effect of Brucine natural alkaloid. This is first development of a formulation that applies Brucine and jojoba oil int a PEGylated liposomal emulgel proposed for topical application. Initially, various PEGylated Brucine liposomal formulations were fabricated using a thin-film hydration method. (22) Factorial design was assembled using two factors (egg Phosphatidylcholine and cholesterol concentrations) and three responses (particle size, encapsulation efficiency and in vitro release). The optimized formula was incorporated within jojoba oil emulgel. The PEGylated liposomal emulgel was inspected for its characteristics, in vitro, ex vivo and anti-inflammatory behaviors. Liposomal emulgel showed a pH of 6.63, a spreadability of 48.8 mm and a viscosity of 9310 cP. As much as 40.57% of Brucine was released after 6 h, and drug permeability exhibited a flux of 0.47 µg/cm2·h. Lastly, % of inflammation was lowered to 47.7, which was significant effect compared to other formulations. In conclusion, the anti-inflammatory influence of jojoba oil and Brucine was confirmed, supporting their integration into liposomal emulgel as a potential nanocarrier.

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“…All topical novel formulations, such as the lipid carrier and vesicular systems, must have approved ingredients or GRAS materials [26][27][28][29][30][31]. Most excipients fall in the GRAS category or have been used in marketing products (Table 1) [7,9,13,[30][31][32][33][34][35][36][37][38][39][40][41][42][43].…”

Section: History Of Lipid Carriers and Vesiclesmentioning

confidence: 99%

“…The ethosomal system is used to deliver anticancer drugs for skin cancers. The use of paclitaxel-bearing ethosomes in the skin enhanced the penetration of paclitaxel in the membrane model of the stratum corneum-epidermis, and increased its antineoplastic activity in the model of squamous-cell carcinoma, particularly in comparison to the free drug suspension [7,35]. The alcohol in the ethosome initiates transdermal penetration and drug release, with the effect of improving penetration.…”

Section: Applications Of Ultraflexible and Elastic Vesicles In Cancermentioning

confidence: 99%

Ultraflexible Liposome Nanocargo as a Dermal and Transdermal Drug Delivery System

et al. 2021

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A selected active pharmaceutical ingredient must be incorporated into a cargo carrier in a particular manner so that it achieves its goal. An amalgamation of active pharmaceutical ingredients (APIs) should be conducted in such a manner that it is simple, professional, and more beneficial. Lipids/polymers that are known to be used in nanocarriers for APIs can be transformed into a vesicular formulation, which offers elegant solutions to many problems. Phospholipids with other ingredients, such as ethanol and water, form suitable vesicular carriers for many drugs, overcoming many problems related to poor bioavailability, poor solubility, etc. Ultraflexible liposomes are novel carriers and new frontiers of drug delivery for transdermal systems. Auxiliary advances in vesicular carrier research have been made, enabling polymer-coated ethanolic liposomes to avoid detection by the body’s immune system—specifically, the cells of the reticuloendothelial system. Ultraflexible liposomes act as a cargo system and a nanotherapeutic approach for the transport of therapeutic drugs and bioactive agents. Various applications of liposome derivatives in different diseases are emphasized in this review.

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Transdermal ethosomal gel nanocarriers; a promising strategy for enhancement of anti-hypertensive effect of carvedilol

Cited by 44 publications

References 40 publications

Ethosomes-based gel formulation of karanjin for treatment of acne vulgaris: in vitro investigations and preclinical assessment

Ethosomes-based gel formulation of karanjin for treatment of acne vulgaris: in vitro investigations and preclinical assessment

Quality by Design for Optimizing a Novel Liposomal Jojoba Oil-Based Emulgel to Ameliorate the Anti-Inflammatory Effect of Brucine

Ultraflexible Liposome Nanocargo as a Dermal and Transdermal Drug Delivery System

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