Transdermal nitroglycerine enhances the post-operative analgesic effect of intrathecal clonidine in abdominal hysterectomies

Khandelwal, Mamta; Ahmed, Firoz; Garg, Ashish; Verma, Arun; Aquil,; Cs, Chatterjee

doi:10.4103/0019-5049.93352

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…[23] The addition of clonidine (50 μg) to bupivacaine was significantly prolonged the time to first analgesic request. [24] In our study the heart rate and mean atrial blood pressure of patients were comparable in both clonidine and fentanyl groups. The overall haemodynamic stability was observed in both clonidine (30 μg) and fentanyl (15 μg) with in bupivacaine.…”

Section: Discussionsupporting

confidence: 46%

To Compare Analgesic Activity of Intrathecal Clonidine and Fentanyl With Hyperbaric Bupivacaine in Patients of Anorectal Surgery

Yadav¹,

Mishra²,

Bogra³

et al. 2019

jemds

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BACKGROUND There are various adjuvants used along with bupivacaine but clonidine and fentanyl both prolong sensory and motor block and duration of analgesia. In this study we aim to evaluate the onset and duration of sensory and motor block, post-operative analgesia, and adverse effects of clonidine and fentanyl as an adjuvant with hyperbaric bupivacaine in patients of anorectal surgery. METHODS This prospective randomized controlled trial was performed among 60 patients of either sex, aged 18-60 years who belonged to ASA I to III. Group I (BF) received 0.5% hyperbaric bupivacaine (0.5 ml) and fentanyl (15 μg) and Group II (BC) received 0.5% hyperbaric bupivacaine (0.5 ml) and clonidine (30 μg). The onset and duration of sensory and motor block, post-operative analgesia, VAS score, hemodynamic parameters, sedation and adverse effects were recorded and analysed. RESULTS The onset of sensory block was comparable in group BF (8.83 ± 1.62) and group BC (8.16 ± 1.37). The onset of motor block was faster in group BC (8.90±1.24) as compared to group BF (9.70 ± 1.66). The mean time for 2 segment regression, duration of sensory block and duration of motor block were significantly lower (<0.001) in group BC as compared to group BF. CONCLUSIONS Low-dose of intrathecal clonidine as an adjuvant to hyperbaric bupivacaine provided prolonged duration of sensory block and postoperative analgesia with more sedation as compared to intrathecal fentanyl.

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Section: Discussionsupporting

confidence: 46%

To Compare Analgesic Activity of Intrathecal Clonidine and Fentanyl With Hyperbaric Bupivacaine in Patients of Anorectal Surgery

Yadav¹,

Mishra²,

Bogra³

et al. 2019

jemds

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“…Khandelwal et al . [ 18 ] found that time to first analgesic request is prolonged by addition of clonidine in a dose of 50 μg. In their study, total duration of analgesia was 302 ± 54 which was more than that observed in our study because they used a higher dose of clonidine.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of the effect of clonidine, fentanyl, and the combination of both as adjuvant to intrathecal bupivacaine for postoperative analgesia in total abdominal hysterectomy

Ahmed

Khandelwal

Sharma

2017

J Anaesthesiol Clin Pharmacol

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Background and Aims:The aim of this study was to evaluate the level of sensory block, onset and duration of motor block, postoperative analgesia, and adverse effects of combination of clonidine and fentanyl given intrathecally with hyperbaric bupivacaine (HB).Material and Methods:Three hundred and twenty eight patients were randomized into four groups. Group bupivacaine (group B) received 15 mg of HB; group bupivacaine clonidine (group BC) received 15 mg of HB plus 25 μg clonidine; group bupivacaine fentanyl (group BF) received 15 mg of HB plus 25 μg fentanyl and group bupivacaine clonidine fentanyl (group BCF) received 15 mg of HB plus 25 μg clonidine and 25 μg fentanyl intrathecally. All groups were evaluated for level of sensory block, onset and duration of motor block, postoperative analgesia, VAS score, sedation score and adverse effects of study drugs. All the data were analyzed using unpaired t-test. P < 0.05 was considered significant.Results:The level of sensory block, onset, and duration of motor block were comparable in all groups. Total duration of analgesia was 407.3 ± 20 min in group BCF compared to 242.1 ± 2 min and 209.2 ± 16 in groups BC and BF, respectively. Lesser doses of rescue analgesic were required in group BCF. The time interval from intrathecal injection to two-segment regression was statistically significant in study groups. Only 2.4% patients showed mild sedation in BCF group.Conclusion:We found that combination of intrathecal clonidine and fentanyl along with bupivacaine increases the total duration of analgesia without significant side effects.

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Medicinal Patches and Drug Nanoencapsulation: A noninvasive Alternative

Lissarrague

Garate

Lamanna

et al. 2013

Nanomedicine for Drug Delivery and Therapeutics

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Transdermal nitroglycerine enhances the post-operative analgesic effect of intrathecal clonidine in abdominal hysterectomies

Cited by 3 publications

References 9 publications

To Compare Analgesic Activity of Intrathecal Clonidine and Fentanyl With Hyperbaric Bupivacaine in Patients of Anorectal Surgery

To Compare Analgesic Activity of Intrathecal Clonidine and Fentanyl With Hyperbaric Bupivacaine in Patients of Anorectal Surgery

A comparative study of the effect of clonidine, fentanyl, and the combination of both as adjuvant to intrathecal bupivacaine for postoperative analgesia in total abdominal hysterectomy

Medicinal Patches and Drug Nanoencapsulation: A noninvasive Alternative

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