Transdermal testosterone replacement therapy in men

Abstract

Androgen deficiency syndrome in men is a frequently diagnosed condition associated with clinical symptoms including fatigue, decreased libido, erectile dysfunction, and metabolic syndrome. Serum testosterone concentrations decline steadily with age. The prevalence of androgen deficiency syndrome in men varies depending on the age group, known and unknown comorbidities, and the respective study group. Reported prevalence rates may be underestimated, as not every man with symptoms of androgen deficiency seeks treatment. Additionally, men reporting symptoms of androgen deficiency may not be correctly diagnosed due to the vagueness of the symptom quality. The treatment of androgen deficiency syndrome or male hypogonadism may sometimes be difficult due to various reasons. There is no consensus as to when to start treating a respective man or with regards to the best treatment option for an individual patient. There is also lack of familiarity with treatment options among general practitioners. The formulations currently available on the market are generally expensive and dose adjustment protocols for each differ. All these factors add to the complexity of testosterone replacement therapy. In this article we will discuss the general indications of transdermal testosterone replacement therapy, available formulations, dosage, application sites, and recommended titration schedule.

Medicinal Use of Testosterone and Related Steroids Revisited

“…The usual mode of administration includes injections or subcutaneous implants of its ester forms. Dermal patches are available and this is the method of choice for the treatment of hypogonadism [ 1 , 7 ]. T is also available in other therapeutic modalities, including topical hydroalcoholic gels [ 8 ], buccal [ 9 ], sublingual [ 10 ], and intranasal formulations [ 11 ].…”

Contemporary treatment options for male hypogonadism

“…Wyróżnia się preparaty testosteronu w postaci żelu, plastrów, roztworów do stosowania na skórę. Stosowanie systemów transdermalnych może wiązać się z niedogodnościami takimi jak, ryzyko przeniesienia preparatu na inną osobę, oraz ryzyko podrażnienia skóry [29]. https://pubchem.ncbi.nlm.nih.gov/compound/Testosterone-cypionate[25] https://pubchem.ncbi.nlm.nih.gov/compound/Testosterone-undecanoate[26] Piśmiennictwo 1.…”

Természetes és mesterséges hormonhiány kiváltotta kardiovaszkuláris változások és terápiás lehetőségei patkánymodellben

“…A transzdermális TPT egy fájdalommentes, könnyebb alkalmazási forma, mely gélek vagy krémek mindennapos bőrre történő kenésével valósul meg [92]. A tesztoszteron visszapótlásán kívül elérhetőek alternatív, például LH működést utánzó, vagy az aromatáz enzim gátlásával megvalósuló terápiás módszerek is hormonhiányos betegek számára.…”