Transdiagnostic emotional vulnerabilities linking obsessive-compulsive and depressive symptoms in a community-based sample of adolescents

Chasson, Gregory S.; Bello, S B S Mariel; Luxon, Alexandria M.; Graham, Adam; Leventhal, Adam M.

doi:10.1002/da.22669

Cited by 18 publications

(14 citation statements)

References 65 publications

(104 reference statements)

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“…A substantial proportion (27%) of studies did not acknowledge using any psychometric interview to establish their gold standard diagnoses. Several studies (16%) did not refer to a gold standard diagnostic manual, but speculated on comparative benefits of the transdiagnostic approach over specific diagnoses.…”

Section: Resultsmentioning

confidence: 99%

“…Some studies used comorbid (as opposed to primary) diagnoses to validate the transdiagnostic construct. In about one third of studies (28%), the boundaries between primary and secondary diagnoses were not completely clear.…”

Section: Resultsmentioning

confidence: 99%

“…The number of primary mental disorders investigated by each study was highly variable and overall relatively low, ranging from no evidence of mental disorders at all (13% of studies) and one mental disorder (8% of studies), up to 353 mental disorders (median: four mental disorders per study). Similarly, the number of ICD‐defined diagnostic spectra was heterogeneous, ranging from zero (12% of studies) to ten (median: one spectrum) per study. The largest transdiagnostic study published to date leveraged an electronic case register to include 353 mental disorders clustered across ten spectra, representing all ICD‐10 mental disorders except organic mental disorders.…”

Section: Resultsmentioning

confidence: 99%

“…The largest transdiagnostic study published to date leveraged an electronic case register to include 353 mental disorders clustered across ten spectra, representing all ICD‐10 mental disorders except organic mental disorders. About one third of the studies (35%) included at least one non‐clinical sample.…”

Section: Resultsmentioning

confidence: 99%

“…The exact definition of the transdiagnostic construct per study is provided in Table . Only a minority of constructs (36%) involved multiple processes. Most studies (81%) were descriptive in nature.…”

Section: Resultsmentioning

confidence: 99%

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Transdiagnostic psychiatry: a systematic review

et al. 2019

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The usefulness of current psychiatric classification, which is based on ICD/DSM categorical diagnoses, remains questionable. A promising alternative has been put forward as the "transdiagnostic" approach. This is expected to cut across existing categorical diagnoses and go beyond them, to improve the way we classify and treat mental disorders. This systematic review explores whether self-defining transdiagnostic research meets such high expectations. A multi-step Web of Science literature search was performed according to an a priori protocol, to identify all studies that used the word "transdiagnostic" in their title, up to May 5, 2018. Empirical variables which indexed core characteristics were extracted, complemented by a bibliometric and conceptual analysis. A total of 111 studies were included. Most studies were investigating interventions, followed by cognition and psychological processes, and neuroscientific topics. Their samples ranged from 15 to 91,199 (median 148) participants, with a mean age from 10 to more than 60 (median 33) years. There were several methodological inconsistencies relating to the definition of the gold standard (DSM/ICD diagnoses), of the outcome measures and of the transdiagnostic approach. The quality of the studies was generally low and only a few findings were externally replicated. The majority of studies tested transdiagnostic features cutting across different diagnoses, and only a few tested new classification systems beyond the existing diagnoses. About one fifth of the studies were not transdiagnostic at all, because they investigated symptoms and not disorders, a single disorder, or because there was no diagnostic information. The bibliometric analysis revealed that transdiagnostic research largely restricted its focus to anxiety and depressive disorders. The conceptual analysis showed that transdiagnostic research is grounded more on rediscoveries than on true innovations, and that it is affected by some conceptual biases. To date, transdiagnostic approaches have not delivered a credible paradigm shift that can impact classification and clinical care. Practical "TRANSD"iagnostic recommendations are proposed here to guide future research in this field.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Transdiagnostic psychiatry: a systematic review

et al. 2019

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Classification of comorbidity in obsessive–compulsive disorder: A latent class analysis

et al. 2020

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Objective Patients with OCD differ markedly from one another in both number and kind of comorbid disorders. In this study, we set out to identify and characterize homogeneous subgroups of OCD patients based on their comorbidity profile. Methods In a cohort of 419 adult subjects with OCD, the lifetime presence of fifteen comorbid disorders was assessed. Latent class analysis was used to identify comorbidity‐based subgroups. Groups were compared with regard to core clinical characteristics: familiality, childhood trauma, age at onset, illness severity, OCD symptom dimensions, personality characteristics, and course of illness. Results The study sample could be divided in a large group ( n = 311) with a low amount of comorbidity that could be further subdivided into two subgroups: OCD simplex ( n = 147) and OCD with lifetime major depressive disorder ( n = 186), and a group ( n = 108) with a high amount of comorbidity that could be further subdivided into a general anxiety‐related subgroup ( n = 49), an autism/social phobia‐related subgroup ( n = 27), and a psychosis/bipolar‐related subgroup ( n = 10). Membership of the high‐comorbid subgroup was associated with higher scores on childhood trauma, illness severity, and the aggression/checking symptom dimension and lower scores on several personality characteristics. Conclusion Grouping OCD patients based on their comorbidity profile might provide more homogeneous, and therefore, more suitable categories for future studies aimed at unraveling the etiological mechanisms underlying this debilitating disorder.

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