2021
DOI: 10.1101/2021.08.05.455314
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Transduction mechanisms for cold temperature in mouse trigeminal and vagal ganglion neurons innervating different peripheral organs

Abstract: Thermal signals are critical elements in the operation of interoceptive and exteroceptive neural circuits, essential for triggering thermally-driven reflexes and conscious behaviors. A fraction of cutaneous and visceral sensory endings are activated by cold temperatures. Compared to somatic (DRG and TG) neurons, little is known about the mechanisms underlying cold sensitivity of visceral vagal neurons. We used pharmacological and genetic tools for a side-by-side characterization of cold-sensitive (CS) neurons … Show more

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