Transepidermal retinoic acid delivery using ablative fractional radiofrequency associated with acoustic pressure ultrasound for stretch marks treatment

Abstract

Ablative fractional RF and acoustic pressure US associated with retinoic acid 0.05% cream is safe and effective for alba-type SD treatment.

Fractionated CO2 Laser in the Treatment of Striae Alba in Darker Skinned Patients - A Prospective Study

“…16 Application of topical retinols, fruit acids, vitamin C, and other medicaments have been recommended for the treatment of striae rubra in its early stages, but all have moderate efficacy. 17,18 Topical tretinoin improve the appearance of striae rubra significantly [19][20][21][22] ; however, it is contraindicated in breastfeeding or pregnant women due to its probable teratogenic side effects. 23,24 Several studies have reported the improvement of the clinical appearance of striae with 585-nm pulsed dye laser (PDL) via enhancement of the extracellular matrix collagen.…”

Transepidermal delivery of cosmeceuticals using radiofrequency and ultrasound: Study of the penetration of a cosmetic gel in vivo by fluorescence microscopy

“…This device was designed to cause thermal damage and fractional ablation to the tissue, while allowing for the introduction of drugs or cosmeceuticals into the dermis [6][7][8][9][10]. This method consists of the creation of microchannels, which theoretically cross the Dermo-Epidermal Junction, and through which the introduction of topically applied substances can be forced by means of ultrasound.…”

“…These microchannels can be created using a fractional CO 2 laser [9] or radiofrequency [10]. Immediately after, ultrasound is used to permeabilize the channels and force the topically applied products through them to the interior of the dermis [6][7][8][9][10].…”

“…Other authors have achieved excellent results in treating hypertrophic scars and stretch marks [6][7][8]. Nonetheless, it would seem that this therapeutic effect is primarily due to the radiofrequency applied, rather than the effects of the drugs or molecules that in theory have been delivered into the skin.…”

“…Nonetheless, it would seem that this therapeutic effect is primarily due to the radiofrequency applied, rather than the effects of the drugs or molecules that in theory have been delivered into the skin. It has been considered that using this method may involve an effective penetration of platelet-rich plasma [6], retinoic acid [7], triamcinolone [8] and cosmeceuticals [9,10], but, to date, there has been no evidence of these products reaching the dermis.…”