Transfer Factor as an Option for Managing the COVID-19 Pandemic

Viza, D.; Pizza, G.; De Vinci, C.; Brandi, G.; Ablashi, Dharam

doi:10.14712/fb2020066030086

Cited by 6 publications

(3 citation statements)

References 41 publications

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“…The spread of the disease is also exacerbated by viral shedding, a common biological process observed in symptomatic patients (Long et al, 2021). The COVID-19 course is influenced not only by host immune system variability (Paces et al, 2020), but an important factor is also genetic predisposition, which has been shown to be a predictor of both susceptibility to infection and COVID-19 severity (Kostrouch, 2020;Viza et al, 2020;Hubacek, 2021a;Delanghe and Speeckaert, 2022). Pati et al (2021) reported the results of an in silico study, which identified a potential association between the functional CD14 polymorphism rs2569190 (C-159→T, C-260→T relative to the translation start site) and increased susceptibility to COVID-19.…”

Section: Introductionmentioning

confidence: 99%

CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection in Central European Population

Hubáček,

Philipp,

Májek

et al. 2023

Fol. Biol.

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A 2021 in silico study highlighted an association between the CD14 polymorphism rs2569190 and increased susceptibility to SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19). The aim of our study was to confirm this finding. We analysed the CD14 polymorphism (C→T; rs2569190) in 516 individuals who tested positive for SARS-CoV-2, with differing disease severity (164 asymptomatic, 245 symptomatic, and 107 hospitalized). We then compared these patients with a sample from the general population consisting of 3,037 individuals using a case-control study design. In comparison with carriers of the C allele, TT homozygotes accounted for 21.7 % of controls and 20.5 % in SARS-CoV-2-positive individuals (P = 0.48; OR; 95 % CI – 0.92; 0.73–1.16). No significant differences in the distribution of genotypes were found when considering co-dominant and recessive genetic models or various between-group comparisons. The CD14 polymorphism is unlikely to be an important predictor of COVID-19 in the Caucasian population in Central Europe.

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Section: Introductionmentioning

confidence: 99%

CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection in Central European Population

Hubáček,

Philipp,

Májek

et al. 2023

Fol. Biol.

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“…In this issue of Folia Biologica, Viza and colleagues suggest transfer factor as a potential option for managing the COVID-19 pandemic (Viza et al, 2020). Transfer factor, an activity identified in activated immune cells, which has modulatory effects on cell-mediated immunity, belongs to small regulatory proteins in a broader sense.…”

mentioning

confidence: 99%

“…Transfer factor is a well-suited target for focused research on Covid-19 (SARS-CoV-2) and similar infections, as suggested by Viza et al (2020).…”

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confidence: 99%