Transferrin targeted core-shell nanomedicine for combinatorial delivery of doxorubicin and sorafenib against hepatocellular carcinoma

pH-sensitive micelles self-assembled from polymer brush (PAE-<em>g</em>-cholesterol)-<em>b</em>-PEG-<em>b</em>-(PAE-<em>g</em>-cholesterol) for anticancer drug delivery and controlled release

“…46,47 The cell culture and cytotoxicity assay were similar to those described in previous work. [42][43][44] A series of free DOX, blank, and DOX-PMs were added into wells with the preprepared cells and incubated for 24 h or 48 h, while fresh medium was used as control.…”

Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma

“…208 Consistent conclusion has been drawn in a similar study on a rat model of HCC. 209 The Tf-decorated core-shell NPs loading DOX in poly(vinyl alcohol) nanocore and sorafenib in albumin nanoshell were developed using sequential freeze-thaw/coacervation method by Malarvizhi et al 210 Upon conjugation of Tfs, the cellular uptake of the nanomedicine was significantly increased in HepG2 cells. Besides, notably improved synergistic cytotoxicity and cell death have been observed upon incubation of HepG2 and PLC/PRF/5 cells with the Tf-targeted NPs.…”

Recent insights into nanotechnology development for detection and treatment of colorectal cancer

“…These exciting strategies have served as a base for the next phase of cancer nanomedicine in the clinic. 65,[67][68][69][70] Future prospective Nanoscience applied to cancer research is proving to be a critical and encouraging approach for the eventual elimination or at least chronic control of cancer. Nanotechnology has been making a significant impact on cancer diagnosis and therapeutic management in revolutionary ways.…”