Transformation with Tryptophan Halogenase Genes Leads to the Production of New Chlorinated Alkaloid Metabolites by a Medicinal Plant

Pée, Karl‐Heinz van

doi:10.1002/cbic.201100016

Cited by 9 publications

(3 citation statements)

References 14 publications

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“…The substrate spectra of group F halogenases includes anilines, indoles, azoles, and pyrroles [ 191 , 232 ]. The halogenases can be integrated into biosynthetic pathways of natural products to generate derivatives of the original compound or non-natural products [ 195 , 207 , 229 , 233 , 234 , 235 , 236 , 237 ]. In particular, the introduction of halogens into natural compounds is a promising strategy to improve products like antibiotics and enhance their therapeutic properties [ 238 , 239 ].…”

Section: Two-component Fad-dependent Monooxygenase Systemsmentioning

confidence: 99%

Two-Component FAD-Dependent Monooxygenases: Current Knowledge and Biotechnological Opportunities

Heine

Berkel

Gassner

et al. 2018

Biology

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Flavoprotein monooxygenases create valuable compounds that are of high interest for the chemical, pharmaceutical, and agrochemical industries, among others. Monooxygenases that use flavin as cofactor are either single- or two-component systems. Here we summarize the current knowledge about two-component flavin adenine dinucleotide (FAD)-dependent monooxygenases and describe their biotechnological relevance. Two-component FAD-dependent monooxygenases catalyze hydroxylation, epoxidation, and halogenation reactions and are physiologically involved in amino acid metabolism, mineralization of aromatic compounds, and biosynthesis of secondary metabolites. The monooxygenase component of these enzymes is strictly dependent on reduced FAD, which is supplied by the reductase component. More and more representatives of two-component FAD-dependent monooxygenases have been discovered and characterized in recent years, which has resulted in the identification of novel physiological roles, functional properties, and a variety of biocatalytic opportunities.

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Section: Two-component Fad-dependent Monooxygenase Systemsmentioning

confidence: 99%

Two-Component FAD-Dependent Monooxygenases: Current Knowledge and Biotechnological Opportunities

Heine

Berkel

Gassner

et al. 2018

Biology

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“…In the stricter sense, these reactions are not oxyfunctionalisation reactions as a halogen is incorporated instead of an oxygen atom. [123][124][125][126][127][128][129][130][131][132][133] According to our present knowledge, flavindependent halogenases primarily catalyse the oxidation of halogenides to hypohalous acids (HOCl, HOBr). These are guided by the protein backbone directly and exclusively to the substrate performing the electrophilic halogenation reaction.…”

Section: It Is Also Worth Mentioning Here That Continuously Newmentioning

confidence: 95%

The taming of oxygen: biocatalytic oxyfunctionalisations

et al. 2014

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“…Metabolic engineering has been applied to improve production of secondary metabolites in different culture systems [75]. Metabolic engineering is the targeted and purposeful alteration of metabolic pathways in an organism to achieve better cellular pathways for chemical transformation and regulatory functions of the cells by using recombinant DNA technology [76].…”

Section: Metabolic Engineeringmentioning

confidence: 99%

Application of Plant Cell and Tissue Culture for the Production of Phytochemicals in Medicinal Plants

Pant

2014

Advances in Experimental Medicine and Biology

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Approximately 80% of the world inhabitants depend on the medicinal plants in the form of traditional formulations for their primary health care system well as in the treatment of a number of diseases since the ancient time. Many commercially used drugs have come from the information of indigenous knowledge of plants and their folk uses. Linking of the indigenous knowledge of medicinal plants to modern research activities provides a new reliable approach, for the discovery of novel drugs much more effectively than with random collection. Increase in population and increasing demand of plant products along with illegal trade are causing depletion of medicinal plants and many are threatened in natural habitat. Plant tissue culture technique has proved potential alternative for the production of desirable bioactive components from plants, to produce the enough amounts of plant material that is needed and for the conservation of threatened species. Different plant tissue culture systems have been extensively studied to improve and enhance the production of plant chemicals in various medicinal plants.

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Transformation with Tryptophan Halogenase Genes Leads to the Production of New Chlorinated Alkaloid Metabolites by a Medicinal Plant

Cited by 9 publications

References 14 publications

Two-Component FAD-Dependent Monooxygenases: Current Knowledge and Biotechnological Opportunities

Two-Component FAD-Dependent Monooxygenases: Current Knowledge and Biotechnological Opportunities

The taming of oxygen: biocatalytic oxyfunctionalisations

Application of Plant Cell and Tissue Culture for the Production of Phytochemicals in Medicinal Plants

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