Transforming growth factor beta-1 (TGF-β1) gene single nucleotide polymorphisms (SNPs) and susceptibility to pre-eclampsia in Iranian women: A case–control study

Khani, Masood; Amani, Davar; Taheripanah, Robabeh; Sanadgol, Nima; Feizollahzadeh, Sadegh; Rahmani, Zahra

doi:10.1016/j.preghy.2015.01.002

Cited by 16 publications

(14 citation statements)

References 51 publications

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“…It indicates that miR‐494 is a hypoxia‐induced miRNA. TGF‐β family is up‐regulated in PE patients and may be involved in the pathogenesis of PE . In TGF‐β family, TGF‐β3 is an important growth factor involved in trophoblast differentiation, which is regulated by oxygen .…”

Section: Resultsmentioning

confidence: 99%

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TGF‐β3‐induced miR‐494 inhibits macrophage polarization via suppressing PGE2 secretion in mesenchymal stem cells

Zhao

Miao

et al. 2016

FEBS Letters

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Abnormal macrophage polarization at the maternal-fetal interface may contribute to the development of Preeclampsia (PE). The reason why macrophage polarization changed in PE is still unclear. Decidual mesenchymal stem cells (dMSCs) could regulate macrophage polarization. However, miRNA in dMSCs of PE were maladjusted. Therefore, we speculated that miRNA may affect dMSC-regulated macrophage polarization. In this study, we found that miR-494-overexpressed dMSCs inhibit M2 macrophage polarization and this inhibitory effect is mediated by miR-494-reduced PGE2 secretion. Furthermore, we proved that miR-494 is induced by TGF-b3. In summary, our findings suggest that the high expression of TGF-b3 in PE decidua stimulates miR-494 in dMSCs and attenuates the regulation of MSC switching the macrophage toward M2 type, contributing to an immune imbalance at maternal-fetal interface.

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Section: Resultsmentioning

confidence: 99%

“…High expression of TGF‐β3 in decidua may contribute to the high level of miR‐494 in dMSCs and change adaptive‐immune system cells in PE. In addition to TGF‐β3, TGF‐β1, and TGF‐β2 are also increased in PE . Among them, it is reported that TGF‐β1 could also enhance miR‐494 levels in myeloid‐derived suppressor cells .…”

Section: Discussionmentioning

confidence: 99%

TGF‐β3‐induced miR‐494 inhibits macrophage polarization via suppressing PGE2 secretion in mesenchymal stem cells

Zhao

Miao

et al. 2016

FEBS Letters

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“…Previous epidemiological studies have indicated that various polymorphisms in genes such as interleukin-27, transforming growth factor beta-1, estrogen receptor alpha, cystathionine gamma-lyase, and cyclooxygenase 2 might play a critical role in the development of preeclampsia (Deepthi et al, 2015;El-Beshbishy et al, 2015;Khani et al, 2015;Mrozikiewicz et al, 2015;Ren et al, 2015;Chen et al, 2016). Here, we carried out a case-control study to estimate the role of the MMP-9 -1562 C/T polymorphism in the risk of pre-eclampsia, and we observed that the CT genotype and T allele of MMP-9 -1562 C/T were associated with elevated risk of pre-eclampsia in Chinese pregnant women.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the association between matrix metalloproteinase-9 genetic polymorphisms and development of pre-eclampsia in Chinese pregnant women

Sun

Zhang

et al. 2016

Genet. Mol. Res.

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ABSTRACT. We carried out a case-control study to evaluate the role of MMP-9 -1562 C/T (rs3918242) genetic polymorphism in the risk of pre-eclampsia in Chinese pregnant women. Between March 2013 and January 2015, 107 pregnant women with pre-eclampsia were recruited from the Second Affiliated Hospital of Zhengzhou University. Genotyping of MMP-9 was carried out using polymerase chain reactionrestriction fragment length polymorphism assay. Unconditional logistic regression analyses revealed that women with the CT genotype (OR = 1.81, 95%CI = 1.04-3.11) exhibited significantly higher risk of preeclampsia than those with the wild-type CC genotype. Moreover, individuals carrying the T allele were at higher risk of pre-eclampsia than those carrying the C allele; the adjusted OR (95%CI) was 1.62 2 C. Sun et al. Genetics and Molecular Research 15 (3): gmr.15038355 (1.06-2.47). In conclusion, our study demonstrated that the MMP-9 -1562 C/T polymorphism plays an important role in the development of pre-eclampsia in Chinese women. Further studies with large sample sizes are greatly needed to confirm our findings.

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“…TGF-β is an anti-proliferative and apoptosis inducing cytokine. PE has been associated with elevated TGF-β-induced gene expression due to promoter hypomethylation and, moreover, a SNP in the TGF-β1 pathway was considered to contribute to PE [93,94]. PE is also associated with lower serum IL-33 and ADAMTS12 levels, strongly indicating a reduced remodeling capacity [95].…”

Section: Immunological Backgroundmentioning

confidence: 99%

Immunology of hepatic diseases during pregnancy

2016

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The mother's immune system has to adapt to pregnancy accepting the semi-allograft fetus and preventing harmful effects to the developing child. Aberrations in feto-maternal immune adaptation may result in disease of the mother, such as liver injury. Five pregnancy-associated liver disorders have been described so far, however, little is known concerning immune alterations promoting the respective disease. These liver disorders are pre-eclampsia, hemolysis, elevated liver enzymes, low platelet count (HELLP), acute fatty liver, hyperemesis gravidarum, and intrahepatic cholestasis of pregnancy. On the other hand, pre-existing autoimmune liver injury of the mother can be affected by pregnancy. This review intends to summarize current knowledge linking feto-maternal immunology and liver inflammation with a special emphasis on novel potential biomarkers.

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Transforming growth factor beta-1 (TGF-β1) gene single nucleotide polymorphisms (SNPs) and susceptibility to pre-eclampsia in Iranian women: A case–control study

Cited by 16 publications

References 51 publications

TGF‐β3‐induced miR‐494 inhibits macrophage polarization via suppressing PGE2 secretion in mesenchymal stem cells

TGF‐β3‐induced miR‐494 inhibits macrophage polarization via suppressing PGE2 secretion in mesenchymal stem cells

Investigation of the association between matrix metalloproteinase-9 genetic polymorphisms and development of pre-eclampsia in Chinese pregnant women

Immunology of hepatic diseases during pregnancy

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