Transforming Growth Factor- Beta1 in Relation to Glomerular Filtration Rate in Healthy Elderly Egyptians

Abstract

Background: Owing to high burdens of chronic kidney disease (CKD) worldwide, research targeting early detection of impaired kidney function merits attention. Transforming growth factor-β1 levels (TGF-β1) regulates renal fibrosis and rises in different kidney diseases. Objectives: The present study aimed at evaluating the serum level of TGF-β1 in relation to estimated glomerular filtration rate (eGFR) in elderly healthy individuals. Methods: This cross-sectional study included 55 individuals, aged above 60 years. Serum level of TGF-β1, microalbuminuria and eGFR were estimated. Systolic and diastolic blood pressure were measured. Results: There was a significant negative correlation between GFR and TGF-β1 values (r value= -0.731, P = 0.001). Twenty-four hours urinary proteins and TGF-β1 levels showed a positive significant correlation (r-value = 0.713, p<0.001). There was no statistically significant difference in TGF-β1 values between males and females (P = 0.832). TGF-B showed good sensitivity: 90.7%; poor specificity: 41.7% at a cut-off of 41.5 with AUC: 0.85; p value < 0.001 to be an indicator for reduced e GFR. Conclusions: TGF-β1 levels could be a potential marker for early detection of renal diseases in elderly individuals.