Transforming growth factor β2 (TGF-β2) in pathogenesis of oral submucous fibrosis: An immunohistochemical study

Kamath, Venkatesh V; Satelur, Krishnanand; Rajkumar, Komali; Krishnamurthy, Shruti

doi:10.4103/0975-8844.143053

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“…in his extensive review article stated that biochemical investigations can be considered as biomarkers in OSMF and amino acid levels are increased in OSMF. [ 20 ]…”

Section: Discussionmentioning

confidence: 99%

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Total serum protein estimation and its correlation with clinical and histopathological grading using Masson's Trichrome stain in patients of oral submucous fibrosis

Sannad

Tamgadge

et al. 2017

Contemp Clin Dent

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Objectives:Oral submucous fibrosis (OSMF) caused by dense deposition of collagen fibers which is a protein. There is a plethora of research to evaluate degree of collagen deposition using various simple histochemical techniques, but its correlation with total serum protein (TSP) level has not been explored so far.Materials and Methods:This case–control study comprised total forty samples with thirty cases of OSMF and ten cases were selected as control group, divided into four groups as per Lai et al. classification. Histological grading was also done according to the Rooban et al.'s classification. Blood sample was collected to evaluate TSP estimation. Findings were tabulated, and comparisons were made between clinical, histological, and TSP estimation. Discrete statistical data were analyzed by Chi-square test, ANOVA, and t-test with a statistical analysis package (SPSS version software 6.0).Results:No significant correlation was obtained between clinical staging and histopathological grading. Definite correlation was obtained in TSP and globulin levels of OSMF patients and their grades of fibrosis histopathologically.Conclusion:In the present study, it was observed that biochemical investigations involving assessment of TSP can be used as a diagnostic tool in OSMF, along with histopathological examination.

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“…in his extensive review article stated that biochemical investigations can be considered as biomarkers in OSMF and amino acid levels are increased in OSMF. [ 20 ]…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown that the TSP level in the serum of OSMF patients was found to be significantly higher than that of normal individuals. [ 14 15 16 17 18 20 ]…”

Section: Discussionmentioning

confidence: 99%

Total serum protein estimation and its correlation with clinical and histopathological grading using Masson's Trichrome stain in patients of oral submucous fibrosis

Sannad

Tamgadge

et al. 2017

Contemp Clin Dent

View full text Add to dashboard Cite

show abstract

Transforming growth factor β2 (TGF-β2) in pathogenesis of oral submucous fibrosis: An immunohistochemical study

Cited by 1 publication

References 0 publications

Total serum protein estimation and its correlation with clinical and histopathological grading using Masson's Trichrome stain in patients of oral submucous fibrosis

Total serum protein estimation and its correlation with clinical and histopathological grading using Masson's Trichrome stain in patients of oral submucous fibrosis

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