This study presents a bibliometric analysis of the Technological Pedagogical Content Knowledge (TPACK) model’s evolution in higher education from 2007 to 2023, with 332 publications in WoS. Employing co-citation, bibliographic coupling, and co-word analyses, it examines key trends, thematic clusters, and the role of professional development and institutional support in TPACK integration. Results indicate that while TPACK’s foundational components—technology, pedagogy, and content—are essential, recent trends emphasize adaptability, self-efficacy, and digital competence as crucial for effective technology use. The COVID-19 pandemic further accelerated TPACK’s adoption, underscoring the importance of hybrid learning models and targeted training for educators. This study highlights areas of concentrated research within TPACK while identifying gaps that could inform future studies, providing insights for educators, researchers, and policymakers aiming to foster technology-enhanced teaching. Future directions suggest integrating emerging technologies like AI and virtual reality into TPACK and exploring region-specific factors affecting technology adoption in educational contexts.