2022
DOI: 10.1039/d2ce00764a
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Transforming liquid nicotine into a stable solid through crystallization with orotic acid

Abstract: Many molecular drugs exist as liquid materials, however this state is not necessarily the most viable or stable means to store pharmaceuticals. Crystal engineering can be utilized to isolate these...

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Cited by 4 publications
(11 citation statements)
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“…The interaction environment of the API (S)-nicotinium was analyzed for the (S)-nicotinium gentisate salt described herein. This allowed for a direct comparison of the API interaction environment across several previously reported nicotinium salts, including the family of (S)-nicotinium malate salts [CCDC REF codes: QAXQOZ (Malate I), QAXQOZ01 (L-Malate II), QAXQOZ02 (DL-Malate), and QAXRAM(D-Malate)], as well as the (S)-nicotinium orotate hemihydrate salt (CCDC REF code: PEKXAI) [ 14 , 29 , 30 ]. As seen in Figure 3 , in the fingerprint plots of the Hirshfeld surface a small central spike corresponding to H-H interactions was observed as peaking around 1.1 Å d i (internal distance) × 1.1 Å d e (external distance).…”
Section: Resultsmentioning
confidence: 99%
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“…The interaction environment of the API (S)-nicotinium was analyzed for the (S)-nicotinium gentisate salt described herein. This allowed for a direct comparison of the API interaction environment across several previously reported nicotinium salts, including the family of (S)-nicotinium malate salts [CCDC REF codes: QAXQOZ (Malate I), QAXQOZ01 (L-Malate II), QAXQOZ02 (DL-Malate), and QAXRAM(D-Malate)], as well as the (S)-nicotinium orotate hemihydrate salt (CCDC REF code: PEKXAI) [ 14 , 29 , 30 ]. As seen in Figure 3 , in the fingerprint plots of the Hirshfeld surface a small central spike corresponding to H-H interactions was observed as peaking around 1.1 Å d i (internal distance) × 1.1 Å d e (external distance).…”
Section: Resultsmentioning
confidence: 99%
“…As observed in the nicotinium malate salts and nicotinium orotate hemihydrate salt, it has been shown that nicotine thermal properties in the solid-state can be modulated through the selection of a salt former [ 29 , 30 ]. Through the understanding and application of the thermal properties of an API, further materials may be rationally designed with targeted properties [ 31 ].…”
Section: Resultsmentioning
confidence: 99%
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“…13 These materials utilized forms of malic acid, orotic acid, and gentisic acid to synthesize safer nicotine salts. [14][15][16] In addition, these nicotine salts also possessed enhanced and tunable thermal properties with significantly improved photostability.…”
mentioning
confidence: 99%