Transfusion support in hematopoietic stem cell transplantation

Abstract

Transfusion support for hematopoietic stem cell transplantation (HSCT) is an essential part of supportive care, and compatible blood should be transfused into recipients. As leukocyte antigen (HLA) matching is considered first and as the blood group does not impede HSCT, major, minor, bidirectional, and RhD incompatibilities occur that might hinder transfusion and cause adverse events. Leukocyte reduction in blood products is frequently used, and irradiation should be performed for blood products, except for plasma. To mitigate incompatibility and adverse events, local transfusion guidelines, hospital transfusion committees, and patient management should be considered.

Clinical significance of decreased or loss ofABOblood group expression in acute myeloid leukaemia: A single‐centre retrospective study

“…Group II survived longer and could receive continuous transfusion support [18,22]. the ABO was evident or caused a clinical significance [22].…”

“…Leukocyte reduction was performed using a filter for packed red cells, or a pre-storage leukocyte-filtered packed red cell (FRBC) component was used for transfusion. In the case of platelets, most patients received apheresis platelets, and if apheresis platelets were unavailable, platelet concentrate was regarded as one-sixth of apheresis platelets in this study [18].…”

Effects of tertiary palliative care on the pattern of end‐of‐life care in patients with hematologic malignancies in Korea

“…45,46 There was a significant difference between the PC and non-PC groups in terms of both the frequency and amount of blood transfusions received. Transfusions are frequently performed in patients with HM 47 ; however, transfusions at the EOL are an issue.…”

“…There was a significant difference between the PC and non‐PC groups in terms of both the frequency and amount of blood transfusions received. Transfusions are frequently performed in patients with HM 47 ; however, transfusions at the EOL are an issue. Identifying transfusions as aggressive care is problematic because blood transfusions serve as a vital service for improving the quality of life at EOL for some patients with HMs.…”

Immuno-Hematologic Complexity of ABO-Incompatible Allogeneic HSC Transplantation

“…For bidirectional incompatibility, the RBCs must be group O, while for platelet concentrates and fresh frozen plasma, group AB must be transfused (Table 5). An increased number of transfused units is noted for major and bidirectional incompatibilities compared to minor incompatibilities [40,41]. Platelet transfusion options may be expanded by subgrouping the A antigen.…”