Transgenerational Epigenetic Inheritance of Developmental Origins of Health and Disease

Wu, Wei; Wu, Peihao; Tang, Qiuqin; Lu, Chuncheng

doi:10.1007/978-981-15-3797-4_14

Cited by 1 publication

(1 citation statement)

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“…Studies have shown the impact of various external factors such as geographic variations, time of birth, malnutrition, infectious diseases, and gynecological complications on schizophrenia [ 59 ]. The divergence of developmental trajectories within psychopathologies is believed to be associated with transgenerational inheritance [ 60 ]. Similarly, the intergenerational phenotypic transfer is also linked with psychotic disorders, indicating a direct manifestation of hypertension from the parental generation [ 61 ].…”

Section: Etiology Of Schizophreniamentioning

confidence: 99%

Hidden Role of Gut Microbiome Dysbiosis in Schizophrenia: Antipsychotics or Psychobiotics as Therapeutics?

Munawar

Ahsan

Muhammad

et al. 2021

IJMS

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Schizophrenia is a chronic, heterogeneous neurodevelopmental disorder that has complex symptoms and uncertain etiology. Mounting evidence indicates the involvement of genetics and epigenetic disturbances, alteration in gut microbiome, immune system abnormalities, and environmental influence in the disease, but a single root cause and mechanism involved has yet to be conclusively determined. Consequently, the identification of diagnostic markers and the development of psychotic drugs for the treatment of schizophrenia faces a high failure rate. This article surveys the etiology of schizophrenia with a particular focus on gut microbiota regulation and the microbial signaling system that correlates with the brain through the vagus nerve, enteric nervous system, immune system, and production of postbiotics. Gut microbially produced molecules may lay the groundwork for further investigations into the role of gut microbiota dysbiosis and the pathophysiology of schizophrenia. Current treatment of schizophrenia is limited to psychotherapy and antipsychotic drugs that have significant side effects. Therefore, alternative therapeutic options merit exploration. The use of psychobiotics alone or in combination with antipsychotics may promote the development of novel therapeutic strategies. In view of the individual gut microbiome structure and personalized response to antipsychotic drugs, a tailored and targeted manipulation of gut microbial diversity naturally by novel prebiotics (non-digestible fiber) may be a successful alternative therapeutic for the treatment of schizophrenia patients.

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Section: Etiology Of Schizophreniamentioning

confidence: 99%