Transgenerational mass balance and tissue distribution of PCBs and PCDD/Fs from grass silage and soil into cow-calf continuum

Accumulation Rate, Depuration Kinetics, and Tissue Distribution of Polychlorinated Dibenzo-p-Dioxins and Dibenzofurans (PCDD/Fs) in Suckler Ewes (Ovis aries)

“…When compared to LT muscle, PCDD/F concentrations were higher in the sternal adipose tissue (2.3-fold for the sum TEQ). A similar observation was made for LT muscle and subcutaneous adipose tissue of depurated lactating cows and growing calves . Such a discrepancy among tissue concentrations warrants caution for food safety monitoring.…”

“…Liver sequestration may result from specific hepatic cytochrome P450-binding. 24 Such enrichment, characterized by the liver to adipose tissue ratio in PCDD/F concentrations was already reported in lactating cows, but at a rather lower rate, 34 whereas it was found to be higher in growing lambs ( Figure 6 ). 23 A lower metabolic activity of cytochrome P450 enzymes in sheep was identified as a possible explanation for higher PCDD/F levels in sheep liver.…”

“…Milk monoexponential half-lives were on average 1.8-fold longer in low-yielding cows 15 but 1.3-fold shorter in high-yielding cows 14 than in the EXP ewes of the present study. Such discrepancies may be partly due to the fact that the EXP ewes in this study and high-yielding cows 14 excreted more milk lipids per body lipid mass than the low-yielding cows in Driesen et al., 15 , 34 making milk a more effective excretion pathway in ewes and high-yielding cows. Alternatively, this may point to a higher ewe and high-yielding cow hepatic metabolic rate.…”

Evolution of Chlorinated Paraffin and Olefin Fingerprints in Sewage Sludge from 1993 to 2020 of a Swiss Municipal Wastewater Treatment Plant

“…Because agricultural land is used for feedstock and food production, one can expect that the uptake of CPs via this route is relevant too. Recently, the transfer of polychlorinated biphenyls (PCBs), including dioxin-like PCBs, from contaminated soil to grass-feeding cattle and from milk to calves has been documented (Driesen et al, 2022). Due to similar physicochemical properties of CPs and PCBs, an uptake of CPs from contaminated soils to cows and via dairy products and meat to humans must be expected too.…”

The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease

“…Routes of exposure to dioxins include inhalation, dust ingestion, and skin contact. Dioxins accumulate in the tissues of various animals [ 26 , 27 , 28 , 29 , 30 , 31 ] and cause chloracne, embryotoxicity [ 32 , 33 ] and nephrotoxicity [ 34 ].…”