Transhemispheric Cortical Plasticity Following Contralateral C7 Nerve Transfer: A Rat Functional Magnetic Resonance Imaging Survival Study

Stephenson, J B; Li, Rupeng; Yan, Ji‐Geng; Hyde, James S.; Matloub, Hani S.

doi:10.1016/j.jhsa.2012.12.018

Cited by 22 publications

(9 citation statements)

References 29 publications

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“…Accumulating evidence involving task functional imaging studies in patients with BPAI shows long-term plasticity between cortical hemispheres, in addition to cortical plasticity between neighboring regions in the same hemisphere [7, 25–27]. A study of long-term cortical remodeling in BPAI after contralateral C7 nerve transfer suggests that the motor control of the reinnervated limb was switched from the ipsilateral hemisphere of the affected plexus to the bilateral hemispheres and finally to the contralateral neural network activation [24], which is consistent with animal studies [9, 28]. The studies also suggest time-dependent cortical reorganization.…”

Section: Discussionsupporting

confidence: 58%

Functional connectivity of motor cortical network in patients with brachial plexus avulsion injury after contralateral cervical nerve transfer: a resting-state fMRI study

Wang

Cheng

et al. 2017

Neuroradiology

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IntroductionThe purpose of this study is to assess the functional connectivity of the motor cortical network in patients with brachial plexus avulsion injury (BPAI) after contralateral C7 nerve transfer, using resting-state functional magnetic resonance imaging (RS-fMRI).MethodsTwelve patients with total brachial plexus root avulsion underwent RS-fMRI after contralateral C7 nerve transfer. Seventeen healthy volunteers were also included in this fMRI study as controls. The hand motor seed regions were defined as region of interests in the bilateral hemispheres. The seed-based functional connectivity was calculated in all the subjects. Differences in functional connectivity of the motor cortical network between patients and healthy controls were compared.ResultsThe inter-hemispheric functional connectivity of the M1 areas was increased in patients with BPAI compared with the controls. The inter-hemispheric functional connectivity between the supplementary motor areas was reduced bilaterally.ConclusionsThe resting-state inter-hemispheric functional connectivity of the bilateral M1 areas is altered in patients after contralateral C7 nerve transfer, suggesting a functional reorganization of cerebral cortex.Electronic supplementary materialThe online version of this article (doi:10.1007/s00234-017-1796-0) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 58%

Functional connectivity of motor cortical network in patients with brachial plexus avulsion injury after contralateral cervical nerve transfer: a resting-state fMRI study

Wang

Cheng

et al. 2017

Neuroradiology

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“…Both stroke and neurological trauma (brain trauma and peripheral nerve injury) are clear examples of pathologies where severe neurological damage occurs. St-fMRI and rsfMRI can detect the resulting loss of functionality ( Pawela et al, 2010 ; Yao et al, 2012 ; Niskanen et al, 2013 ; Stephenson et al, 2013 ; Li et al, 2014 ; Shih et al, 2014 ) and connectivity on a functional level ( van Meer et al, 2010a ; Baliki et al, 2014 ; Mishra et al, 2014 ). Interestingly, in most cases this loss of functionality is partially recovered depending on the lesion severity ( Niskanen et al, 2013 ; Shih et al, 2014 ).…”

Section: Fmri Applications With Relevance For Pharmacological Researcmentioning

confidence: 99%

The power of using functional fMRI on small rodents to study brain pharmacology and disease

et al. 2015

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Functional magnetic resonance imaging (fMRI) is an excellent tool to study the effect of pharmacological modulations on brain function in a non-invasive and longitudinal manner. We introduce several blood oxygenation level dependent (BOLD) fMRI techniques, including resting state (rsfMRI), stimulus-evoked (st-fMRI), and pharmacological MRI (phMRI). Respectively, these techniques permit the assessment of functional connectivity during rest as well as brain activation triggered by sensory stimulation and/or a pharmacological challenge. The first part of this review describes the physiological basis of BOLD fMRI and the hemodynamic response on which the MRI contrast is based. Specific emphasis goes to possible effects of anesthesia and the animal’s physiological conditions on neural activity and the hemodynamic response. The second part of this review describes applications of the aforementioned techniques in pharmacologically induced, as well as in traumatic and transgenic disease models and illustrates how multiple fMRI methods can be applied successfully to evaluate different aspects of a specific disorder. For example, fMRI techniques can be used to pinpoint the neural substrate of a disease beyond previously defined hypothesis-driven regions-of-interest. In addition, fMRI techniques allow one to dissect how specific modifications (e.g., treatment, lesion etc.) modulate the functioning of specific brain areas (st-fMRI, phMRI) and how functional connectivity (rsfMRI) between several brain regions is affected, both in acute and extended time frames. Furthermore, fMRI techniques can be used to assess/explore the efficacy of novel treatments in depth, both in fundamental research as well as in preclinical settings. In conclusion, by describing several exemplary studies, we aim to highlight the advantages of functional MRI in exploring the acute and long-term effects of pharmacological substances and/or pathology on brain functioning along with several methodological considerations.

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“…According to Curr et al, NRG1 is required for effective nerve repair and remyelination [ 11 ]. However, there is still much variation in the procedures used in treatment of brachial plexus injuries using contralateral C7 nerve root transfer, such as differences in age, time of reconstruction, length of grafts, and the specific target muscle group [ 12 ]. Based on the above research, the present study estimated the effects of NRG-1 on the recovery of nerve function in brachial plexus injury after contralateral C7 nerve root transfer in a rat model.…”

Section: Introductionmentioning

confidence: 99%

Overexpression of Neuregulin-1 (NRG-1) Gene Contributes to Surgical Repair of Brachial Plexus Injury After Contralateral C7 Nerve Root Transfer in Rats

2018

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BackgroundSurgeons usually transfer the contralateral C7 to the median nerve on the injured side via a nerve graft to recover sensation and movement in a paralyzed hand. The purpose of our study was to determine whether NRG-1 affects the recovery of nerve function in brachial plexus injury after contralateral C7 nerve root transfer in a rat model.Material/MethodsAn injury model of left brachial plexus and contralateral C7 nerve root transfer was established. Four weeks after the operation, NRG-1 expression was examined by reverse transcription quantitative polymerase chain reaction and Western blot analysis. The diameter rate differences of the healthy limb and affected limb were estimated. The postoperative mass of the left latissimus dorsi, triceps, extensor carpi radialis brevis, and musculus extensor digitorum were examined. The number of nerve fibers and typical area of the affected side were assessed. Postoperative left motor nerve conduction velocity (MNCV) and motor nerve action potential (MNAP) were tested by use of a biological information recording and collecting system.ResultsEukaryotic expression plasmid of pcDNA4/myc/A-NRG-1 was successfully constructed, and NRG-1 was overexpressed. Compared with the model group, the NRG-1 group had a lower rate of differences of the limbs; higher mass of left latissimus dorsi, triceps, extensor carpi radialis brevis, and musculus extensor digitorum; more nerve fibers and larger typical area in the affected side, left MNCV, and MNAP; and wider CSA of the left triceps.ConclusionsThese results demonstrated that NRG-1 can promote recovery of nerve function in brachial plexus injury after contralateral C7 nerve root transfer in rats.

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Transhemispheric Cortical Plasticity Following Contralateral C7 Nerve Transfer: A Rat Functional Magnetic Resonance Imaging Survival Study

Cited by 22 publications

References 29 publications

Functional connectivity of motor cortical network in patients with brachial plexus avulsion injury after contralateral cervical nerve transfer: a resting-state fMRI study

Functional connectivity of motor cortical network in patients with brachial plexus avulsion injury after contralateral cervical nerve transfer: a resting-state fMRI study

The power of using functional fMRI on small rodents to study brain pharmacology and disease

Overexpression of Neuregulin-1 (NRG-1) Gene Contributes to Surgical Repair of Brachial Plexus Injury After Contralateral C7 Nerve Root Transfer in Rats

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