Transient and 2-Dimensional Shear-Wave Elastography Provide Comparable Assessment of Alcoholic Liver Fibrosis and Cirrhosis

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“…Reported predictors of unreliable results with SSI are similar to those reported for TE and pSWE [56,117]. In one study, a lower SD and larger analysis boxes independently correlated with correct classifications of severe fibrosis and cirrhosis [114].…”

“…The intraobserver reproducibility of 2D-SWE for liver stiffness assessment in liver fibrosis patients is excellent, with the ICC ranging from 0.90 to 0.95 in published studies [56,57,117]. The intra-subject reproducibility (evaluated over periods of 2 days to 4 weeks) ranges between 0.83 and 0.90 [31].…”

“…The main factors limiting the applicability of 2D-SWE include obesity, poor acoustic window or presence of artefacts and inability of the subjects to hold their breath [26,56,57,59,117].…”

“…TE can be used to exclude cirrhosis in patients with alcoholic liver disease, provided that acute alcoholic hepatitis is not present (LoE 2b, GoR B) [56,214,219,220]. Strong consensus (15/0/0, 100 %)…”

“…[220]. One study suggests that TE is accurate for staging in patients with ongoing alcohol abuse but normal gamma-glutamyltransferase [56], while another study suggests that AUC for the diagnosis of cirrhosis in alcoholic patients diminishes when AST is above 100 -150 U/L [220].…”