Transient aversion and long-lasting amnesia following cycloheximide injection in the rat

Schmaltz, G.; Marcant, Pierre

doi:10.1016/0031-9384(83)90246-9

Cited by 4 publications

(1 citation statement)

References 30 publications

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“…Alternatively, contextual memory can be analyzed by reexposing animals to the training environment. In rats systemic injection of CXM prevented the formation of such contextual memory [183]. The dependence of fear conditioning on de novo protein synthesis is further supported by evidence for an involvement of CREB in this type of learning.…”

Section: Memory Formation In Rodentsmentioning

confidence: 70%

Memory formation and the regulation of gene expression

Stork

Welzl

1999

Cellular and Molecular Life Sciences (CMLS)

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On a cellular level, formation of memory is based on a selective change in synaptic efficacy that is both fast and, in case of important information, long-lasting. Rapidity of cellular changes is achieved by modifying preexisting synaptic molecules (receptors, ion channels), which instantaneously alters the efficacy of synaptic transmission. Endurance, that is the formation of long-term memory (LTM), is based on transient and perhaps also long-lasting changes in protein synthesis. A number of different methods exist to interfere with the synthesis of specific proteins or proteins in general. Other methods, in turn, help to identify proteins whose synthesis is changed following learning. These mostly molecular methods are briefly described in the present review. Their successful application in a variety of memory paradigms in invertebrates and vertebrates is illustrated. The data support the importance of selective changes in gene expression for LTM. Proteins newly synthesized during memory consolidation are likely to contribute to restructuring processes at the synapse. altering the efficiency of transmission beyond the scope of STM. Increased or, less often, decreased synthesis of proteins appears during specific time windows following learning. Recent evidence supports older data suggesting that two or even more waves of protein synthesis exist during the consolidation period. It is expected that the new molecular methods will help to identify and characterize molecules whose expression changes during LTM formation even in complex vertebrate learning paradigms.

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Section: Memory Formation In Rodentsmentioning

confidence: 70%

Memory formation and the regulation of gene expression

Stork

Welzl

1999

Cellular and Molecular Life Sciences (CMLS)

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Extract of Yi Zhi Fang improves learning and memory behaviours of mice and its possible mechanisms

Sun

Shoyama

2002

Phytotherapy Research

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The effects of Yi Zhi Fang extract (YZF) on learning and memory performances were investigated in mice using passive avoidance tasks. Oral administration of YZF improved learning and memory disorders induced by chemicals in both normal and senile mice. The acetylcholine (Ach) concentration, the muscarinic Ach receptors (M-R) and the monoamine oxidase B (MAO-B) activities were analysed by a radioimmunoassay, a radioligand receptor binding assay and UV spectrophotometry, respectively, using senile decapitated mice. The oral administration of YZF to the senile mice increased the M-R concentration, while the concentration of Ach and the activity of MAO-B decreased in senile mice brains. From these results it is evident that YZF promotes the function of the central cholinergic system and inhibits the activity of MAO-B in mice brains resulting in an enhancement of learning and memory.

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