Transient dynamics in electronic neuron-like circuits in application to modeling epileptic seizures

Egorov, Nikita; Kulminskiy, D. D.; Sysoev, Ilya V.; Ponomarenko, V. I.; Sysoeva, Marina V.

doi:10.1007/s11071-022-07379-6

Cited by 5 publications

(3 citation statements)

References 45 publications

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“…Compared to earlier studies [18], [19], in the present experiment all synaptic couplings were analog devices rather than microcontroller based connections using digitized signals; in [36] the coupling was analog, but it was linear and therefore not synaptic-like. The synaptic analog coupling, on the one hand, is much more complicated for implementation.…”

Section: Conclusion and Discussioncontrasting

confidence: 58%

“…From the many variants of mathematical models of biological neurons [11], the FitzHugh-Nagumo neuron model was chosen [12], [13], which is a dimensionless simplified version of the Hodgkin-Huxley model [14], reproducing the basic properties of excitation waves. The main reason for researchers' interest in this model is the simplicity of implementing nonlinear functions, making possible to assemble an electronic model on the simplest elements [15]- [17] or to implement an ensemble of ten or more elements [18] relatively quickly .…”

Section: Introductionmentioning

confidence: 99%

“…Variability inherent for biological systems due to different in detail coupling architecture was also shown. Then, eight hardware circuits consisting of 14 simplified FitzHugh-Nagumo neurons were implemented [18]. The electronic experiment showed that the implemented circuits are able to demonstrate the desired behavior -long-term quasi-regular transients reproducing various characteristics of epileptiform activity.…”

Section: Introductionmentioning

confidence: 99%

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Ring generator of neuron-like activity with tunable frequency

Egorov¹,

Sysoeva²,

Пономаренко³

et al. 2022

AND

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The aim of the work is to build a radiophysical generator of neuron-like activity with a frequency tunable in various ways, corresponding to modern ideas about the structure of the hippocampus and the generation of pathological epileptic rhythms in it. Methods. The elements of the generator are radio engineering implementations of the complete FitzHugh– Nagumo neuron and the electronic implementation of a chemical synapse in the form of a sigmoid function with a delayed argument. The simulation was carried out in the SPICE simulator. Results. Various ways of introducing delay into the coupling are considered: an ideal delay line, a phase filter with a rheostat, one tunable Bessel filter, and a sequence of non-tunable Bessel filters. For circuit implementation, the approach using a Bessel filter with a rheostat is recognized as optimal as a compromise between simplicity and minimization of signal distortion. The dependences of the oscillation frequency on the number of elements in the ring and the delay time are constructed. The bistability of generation regimes is studied for certain values of the parameters. The effect of inclusion of inhibitory elements (interneurons) in the circuit is considered. Conclusion. The constructed ring generator models the experimentally observed properties of the dynamics of epileptic discharge fundamental frequency in limbic epilepsy. It is able to reproduce the occurrence of oscillations as a result of external short-term driving, smooth and sharp frequency tuning, the coexistence of different modes with the same parameters.

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Section: Conclusion and Discussioncontrasting

confidence: 58%