Transient left ventricular dysfunction (tako-tsubo phenomenon): Findings and potential pathophysiological mechanisms

Stöllberger, Claudia; Finsterer, Josef; Schneider, B.

doi:10.1016/s0828-282x(06)70322-1

Cited by 31 publications

(43 citation statements)

References 67 publications

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“…5,6 As Rahimi et al, identify, a similar hypothesis has been advanced to explain the electrocardiographic and left ventricular abnormalities accompanying intracranial hemorrhage. 5 Indeed, it is becoming increasingly plausible that apical and midleft ventricular stunning accompanied by anterolateral electrocardiographic ST-elevations and elevations in cardiac biomarkers may represent a final common pathway for the effects of overwhelming sympathetic discharge, whatever its cause.…”

mentioning

confidence: 89%

“…5 The question we pose is whether differentiating between the ''classic'' presentation of TC and the cardiac abnormalities accompanying intracranial hemorrhage is, in fact, possible. Intracranial hemorrhage has previously been associated with TC, 6 as have multiple additional conditions associated with overwhelming sympathetic tone, 4,5,7 suggesting that the relationship between intracranial hemorrhage, electrocardiographic and left ventricular abnormalities, and TC may be due to a common intermediary.…”

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confidence: 99%

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Cerebral Hemorrhage: Precipitating Event for a Tako‐tsubo‐like Cardiomyopathy?

Nault

Baranchuk

2009

Clinical Cardiology

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confidence: 89%

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confidence: 99%

Cerebral Hemorrhage: Precipitating Event for a Tako‐tsubo‐like Cardiomyopathy?

Nault

Baranchuk

2009

Clinical Cardiology

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“…However, it refers also to the left ventricular apical ballooning observed in patients with ECG changes suggestive of acute coronary syndrome (ST segment elevation or T wave inversion), mildly elevated cardiac markers, left ventricular wall motion abnormalities in the apical region, but normal coronary arteries at the angiogram [1]. To our best knowledge, apical ballooning syndrome or "tako-tsubo" syndrome (TTS) was never clearly identified following drug overdose.…”

Section: Introductionmentioning

confidence: 99%

Tako-tsubo syndrome following nortriptyline overdose

Roock

Beauloye

Bauwer

et al. 2008

Clinical Toxicology

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Background. Tako-tsubo syndrome (TTS) refers to the apical ballooning of the left ventricle observed when angiographic ventriculography is performed in patients presenting with electrocardiographic changes suggestive of acute coronary syndrome (new transient ST-segment deviation (>0.05 mV) or T-wave inversion (>0.2 mV)), mild elevation of cardiac markers, but normal coronary arteries at the angiogram. Case report. A 54-year-old woman developed the characteristic features of TTS 44 hours following nortriptyline overdose. The admission ECG showed increased QRS duration rapidly reversible after sodium bicarbonate infusion. There was a minimal increase in troponin I level. The ECG performed at the time of chest pain revealed deeply negative T waves in leads I, II, III, aVF, V1 to V6 and remained abnormal at 5 weeks follow-up. In contrast, a complete recovery of left ventricular function was observed within one week. Discussion. The pathophysiology of TTS, a variant of myocardial stunning, is still incompletely understood but could be related to sympathetic overstimulation. The possibility of TTS following toxic exposure is discussed.

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“…High catecholamine plasma level as a result of stress-induced sympathetic hyperactivity affects the cardiomyocytes of the left ventricle by b adrenoreceptors, and a complex chain of intracellular second signals [5,6].…”

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confidence: 99%

“…ST-segment elevation usually persists for a few hours and then becomes isoelectric. After some time, ECG shows a deep negative T wave, usually in all precordial leads, that can persist for a few months from the initial symptoms ( Figure 1) [6,7]. For diagnosis of "real" TTS, some criteria must be applied.…”

mentioning

confidence: 99%