Transient leukopenia, thrombocytopenia, and severe neutropenia associated with acute SARS‐CoV‐2 infection

Schatzman, Austin; Vandenheuvel, Julia; Villalobos, Tibisay; Rooney, Kris

doi:10.1002/pbc.29105

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…According to European Society of Clinical Microbiology and Infectious Diseases (ESCMID) guidelines, it is recommended to use tocilizumab in hospitalized patients with severe COVID-19 24 . A study conducted in cancer patients indicated that higher COVID-19 severity was associated with abnormal CRP levels 25 . Another randomized clinical trial on tocilizumab reported that patients with CRP levels above 150 mg/L benefited from tocilizumab treatment 26 .…”

Section: Discussionmentioning

confidence: 99%

The clinical features, treatment and prognosis of neutropenic fever and Coronavirus disease 2019 results of the multicentre teos study

Başkol Elik,

Kaya,

Alkan

et al. 2024

Sci Rep

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This multicentre (22 centres in Turkey) retrospective cohort study aimed to assess the clinical outcomes of patients with neutropenic fever and SARS-CoV-2 positivity. Study period was 15 March 2020–15 August 2021. A total of 170 cases (58 female, aged 59 ± 15.5 years) that fulfilled the inclusion criteria were included in the study. One-month mortality rate (OMM) was 44.8%. The logistic regression analysis showed the following significant variables for the mentioned dependent variables: (i) achieving PCR negativity: receiving a maximum of 5 days of favipiravir (p = 0.005, OR 5.166, 95% CI 1.639–16.280); (ii) need for ICU: receiving glycopeptide therapy at any time during the COVID-19/FEN episode (p = 0.001, OR 6.566, 95% CI 2.137–20.172), the need for mechanical ventilation (p < 0.001, OR 62.042, 95% CI 9.528–404.011); (iii) need for mechanical ventilation: failure to recover from neutropenia (p < 0.001, OR 17.869, 95% CI 3.592–88.907), receiving tocilizumab therapy (p = 0.028, OR 32.227, 95% CI 1.469–707.053), septic shock (p = 0.001, OR 15.4 96% CI 3.164–75.897), and the need for ICU (p < 0.001, OR 91.818, 95% CI 15.360–548.873), (iv) OMM: [mechanical ventilation (p = 0.001, OR 19.041, 95% CI 3.229–112.286) and septic shock (p = 0.010, OR 5.589,95% CI 1.509–20.700)]. Although it includes a relatively limited number of patients, our findings suggest that COVID-19 and FEN are associated with significant mortality and morbidity.

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Section: Discussionmentioning

confidence: 99%

The clinical features, treatment and prognosis of neutropenic fever and Coronavirus disease 2019 results of the multicentre teos study

Başkol Elik,

Kaya,

Alkan

et al. 2024

Sci Rep

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“…SARS-CoV-2 could directly affect hematopoietic cells and bone marrow stromal cells inducing thrombocytopenia. 75 Bacterial sepsis in hospitalized patients may hamper the expression of plasminogen activator inhibitor-1 (PAI-1), therefore, fibrinolysis is interrupted, and more vigorously the number of PLTs will drop in Covid-19 patients. Persistent hypertension, low oxygen levels, and diffused alveolar damage alters the integrity of pulmonary capillary beds and suppresses PLT release.…”

Section: Role Of Haematological Tests In Covid-19 Detectionmentioning

confidence: 99%

Review—Role of Nanomaterials in Screenprinted Electrochemical Biosensors for Detection of Covid-19 and for Post-Covid Syndromes

et al. 2023

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Covid-19 remains a global pandemic surging with different variants like (Omicron) in various countries. An escalation in random testing for Covid-19 is considered as the golden standard by WHO to control the spread of Corona virus. RT-PCR and nucleic acid hybridization strategies are two highly sensitive outstanding tests used for the detection of SARS-CoV-2 in the DNA by the former and RNA/DNA by the later. Apart from the test for virus, antigen, and antibodies, other alternative hematological tests like CRP, Ferritine, IL-6, Blood Platelets and WBC, and plasma became essential for the detection and management of Covid-19. Overcoming the limitations of a rapid, efficient, low-cost, and easy-to-implement test kits are in imperative need to meet these requirements. Electrochemical sensors are considered as potential and ultrafast point-of-care sensors used as self-testing kits. In this work, we review the various modified electrodes with different nanomaterials such as graphene, CNTs, and nano-dopants used as electrochemical sensors in association with testing various different parameters for detection of covid-19. A detailed discussion on the merits of present testing patterns and scope of screen-printed electrochemical sensors modified with different nanomaterials and their advantages is presented.

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“…Destruction of the bone marrow, commonly seen in hematological diseases, might lead to leukopenia as the production of leukocytes is located in the bone marrow. Further reasons for leukopenia include vitamin deficiency (especially vitamin B 12 ), folic acid and copper deficiency, toxic and radiation damage, as well as autoimmune diseases and infectious diseases (such as HIV and SARS-CoV-2) [ 10 , 11 , 12 ]. Several drugs are known to be associated with leukopenia by inducing apoptosis, inhibiting leukocyte development, or being toxic for myeloid precursor cells [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Morbidity and Mortality of Neutropenic Patients in Visceral Surgery: A Narrative Review

Lederer

Bartsch

Möhler

et al. 2022

Cells

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Leukocytes are essential for the function of the immune system and cell–cell interaction in the human body, but hematological diseases as well as chemotherapeutic treatments due to cancer lead to occasionally or even permanent leukocyte deficiency. Normally, more than 50% of leukocytes are neutrophilic granulocytes, and leukopenia is, therefore, mostly characterized by a decrease in neutrophilic granulocytes. The consequence of neutropenia is increased susceptibility to infection, but also healing disorders are suggestable due to the disturbed cell–cell interaction. While there is no surgical treatment for leucocyte disorders, patients suffering from neutropenia are sometimes in need of surgery for other reasons. Less is known about the morbidity and mortality of this patients, which is why this narrative review critically summarizes the results of recent research in this particular field. The results of this review suggest that neutropenic patients in need of emergency surgery have a higher mortality risk compared to non-neutropenic patients. In contrast, in elective surgery, there was not a clear tendency for a higher mortality risk of neutropenic patients. The role of neutrophilic granulocytes in inflammation and immunity in surgical patients is emphasized by the results, but most of the evaluated studies showed methodological flaws due to small sample sizes or risk of bias. Further research has to evaluate the risk for postoperative complications, particularly of infectious complications such as surgical site infections, in neutropenic patients undergoing elective surgery, and should address the role of neutrophilic function in postoperative morbidity and mortality.

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Transient leukopenia, thrombocytopenia, and severe neutropenia associated with acute SARS‐CoV‐2 infection

Cited by 4 publications

References 13 publications

The clinical features, treatment and prognosis of neutropenic fever and Coronavirus disease 2019 results of the multicentre teos study

The clinical features, treatment and prognosis of neutropenic fever and Coronavirus disease 2019 results of the multicentre teos study

Review—Role of Nanomaterials in Screenprinted Electrochemical Biosensors for Detection of Covid-19 and for Post-Covid Syndromes

Morbidity and Mortality of Neutropenic Patients in Visceral Surgery: A Narrative Review

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