Transient receptor potential channels in multiple myeloma (Review)

Meng, Lingjun; Gu, Gui‑ying; Bi, Lintao

doi:10.3892/ol.2022.13228

Cited by 9 publications

(5 citation statements)

References 68 publications

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“…Numerous studies have been conducted to investigate the impact of TRPV2 on cell migration, 16,26,44 yet very few have focused on bone cells. 45 This current study is the pioneering endeavor to elucidate the consequences of TRPV2 knockdown on the migratory capability of RAW264.7 cells under gradient FSS. It is worth noting, however, that several limitations exist within our study.…”

Section: Discussionmentioning

confidence: 99%

Knockdown of TRPV2 inhibits the migration of RAW264.7 cells toward low fluid shear stress region

Gao,

Zhang,

Huo

2023

J of Cellular Biochemistry

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Our previous studies have demonstrated that macrophages (RAW264.7) have a special ability for sensing the gradient of fluid shear stress (FSS) and migrate toward the low‐FSS region. However, the molecular mechanism regulating this phenomenon is still unclear. In this study, we examined the transcriptome genes in RAW264.7 cells, MC3T3‐E1 osteoblasts, mesenchymal stem cells, canine renal epithelial cells, and periodontal ligament cells. The expression levels of genes related to cell migration, force transfer, and force sensitivity in the Ca2+ signaling pathway were analyzed. We observed that the transient receptor potential cation channel type 2 (TRPV2) was highly expressed in RAW264.7 cells. Furthermore, we used lentiviral transfection to knockdown TRPV2 expression in RAW264.7 cells and studied the effect of TRPV2 on the migration of RAW264.7 cells under a gradient FSS field. The results showed that compared with normal cells, TRPV2‐knockdown cells had impaired ability for sensing FSS gradient to migrate toward the low‐FSS region and lower intracellular calcium response to FSS stimulation. This study may reveal the molecular mechanism of regulating the directional migration of macrophages under a gradient FSS field.

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Section: Discussionmentioning

confidence: 99%

Knockdown of TRPV2 inhibits the migration of RAW264.7 cells toward low fluid shear stress region

Gao,

Zhang,

Huo

2023

J of Cellular Biochemistry

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“…Studies in this area are not yet managed in China. In China, current treatments, including bortezomib, are broadly used than before, followed by satisfactory results [23].…”

Section: Discussionmentioning

confidence: 99%

Impact of Initial Renal Involvement and Bence Jones Proteins in the Urine on Overall Survival of Patients With Multiple Myeloma

Balkanov

Trajkova

Veljanovska

et al. 2022

JMS

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Multiple myeloma (MM) is a cancer of plasma cells with a frequency of around 50 cases per million population (pmp)/year. This retrospective study was conducted at the University Clinic for Hematology in Skopje, North Macedonia, in the period between January 2009 and December 2019.The cohort group was consisted of 296 recently diagnosed patients with MM. According to the results of our study, in 47% of patients who did not have renal involvement (RI), the survival rate was more than 60 months. On the other side, the survival percentage in those patients who had ARI (acute renal impairment) was 9% and in those who had CRI (chronic renal impairment) only 10%.Forty percent of patients with a negative Bence Jones proteinuria survived more than 60 months. Besides, only 20% of patients with a positive Bence Jones proteinuria survived more than 60 months. Nowadays, bortezomib is generally used as a first-line drug in the treatment of MM in patients with serious RI. In conclusion, there are various research questions that can differentiate the treatment of patients with MM and RI in the near future.

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“…TRPM7 has been shown to be upregulated in myeloma cells compared with normal plasma cells. The knockdown or inhibition of TRPM7 inhibited myeloma cell migration and dissemination [190,191]. Myeloma cell motility and dissemination were suggested to be modulated by the Ca 2+ influx-O-GlcNAcylation regulatory axis linked to integrin α4 and β7.…”

Section: Multiple Myelomamentioning

confidence: 99%

The Role of TRPM7 in Oncogenesis

Köles,

Ribiczey,

Szebeni

et al. 2024

IJMS

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This review summarizes the current understanding of the role of transient receptor potential melastatin-subfamily member 7 (TRPM7) channels in the pathophysiology of neoplastic diseases. The TRPM family represents the largest and most diverse group in the TRP superfamily. Its subtypes are expressed in virtually all human organs playing a central role in (patho)physiological events. The TRPM7 protein (along with TRPM2 and TRPM6) is unique in that it has kinase activity in addition to the channel function. Numerous studies demonstrate the role of TRPM7 chanzyme in tumorigenesis and in other tumor hallmarks such as proliferation, migration, invasion and metastasis. Here we provide an up-to-date overview about the possible role of TRMP7 in a broad range of malignancies such as tumors of the nervous system, head and neck cancers, malignant neoplasms of the upper gastrointestinal tract, colorectal carcinoma, lung cancer, neoplasms of the urinary system, breast cancer, malignant tumors of the female reproductive organs, prostate cancer and other neoplastic pathologies. Experimental data show that the increased expression and/or function of TRPM7 are observed in most malignant tumor types. Thus, TRPM7 chanzyme may be a promising target in tumor therapy.

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Transient receptor potential channels in multiple myeloma (Review)

Cited by 9 publications

References 68 publications

Knockdown of TRPV2 inhibits the migration of RAW264.7 cells toward low fluid shear stress region

Knockdown of TRPV2 inhibits the migration of RAW264.7 cells toward low fluid shear stress region

Impact of Initial Renal Involvement and Bence Jones Proteins in the Urine on Overall Survival of Patients With Multiple Myeloma

The Role of TRPM7 in Oncogenesis

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