Transient receptor potential vanilloid 3 expression is increased in non‐lesional skin of atopic dermatitis patients

Vasas, Nikolett; Pénzes, Zsófia; Kistamás, Kornél; Nánási, Péter P.; Molnár, Szabolcs; Szegedi, Andrea; Szöllősi, Attila Gábor; Bı́ró, Tamás

doi:10.1111/exd.14530

Cited by 9 publications

(4 citation statements)

References 33 publications

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“… 33 TRPV3 is a member of the vanilloid subfamily or TRPV channels and is highly expressed in skin keratinocytes where it forms Ca 2+ -permeable non-selective cation channels to regulate various cutaneous functions. 34 , 35 , 36 , 37 , 38 , 39 , 40 TRPV3 plays an important role in many cutaneous sensations, including nociception, thermal sensing, and itching. 36 , 38 Keratinocytes also express other TRPV channels, such as TRPV1 and TRPV4.…”

Section: Discussionmentioning

confidence: 99%

Heat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway

Zhang¹,

Zeng²,

Jiang³

et al. 2023

iScience

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Section: Discussionmentioning

confidence: 99%

Heat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway

Zhang¹,

Zeng²,

Jiang³

et al. 2023

iScience

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“…[93] TRPV3 levels are increased in skin biopsies of patients with several chronic itch diseases such as atopic dermatitis (AD), rosacea, and psoriasis. [38,[93][94][95][96][97] Intradermal injection of carvacrol, a TRPV3 agonist, induces clear scratching behaviors in mice, [98] whereas pharmacological application of TRPV3 antagonists like dyclonine, citrusinine-II, trpvicin, and osthole alleviate scratching behaviors in several itch models. [41,15,40] TRPV3 activity also modulates cutaneous inflammation.…”

Section: Trpv3 In Cutaneous Physiology and Pathophysiologymentioning

confidence: 99%

Unlocking the therapeutic potential of TRPV3: Insights into thermosensation, channel modulation, and skin homeostasis involving TRPV3

Lei,

Tominaga

2024

BioEssays

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Recent insights reveal the significant role of TRPV3 in warmth sensation. A novel finding elucidated how thermosensation is affected by TRPV3 membrane abundance that is modulated by the transmembrane protein TMEM79. TRPV3 is a warmth‐sensitive ion channel predominantly expressed in epithelial cells, particularly skin keratinocytes. Multiple studies investigated the roles of TRPV3 in cutaneous physiology and pathophysiology. TRPV3 activation by innocuous warm temperatures in keratinocytes highlights its significance in temperature sensation, but whether TRPV3 directly contributes to warmth sensations in vivo remains controversial. This review explores the electrophysiological and structural properties of TRPV3 and how modulators affect its intricate regulatory mechanisms. Moreover, we discuss the multifaceted involvement of TRPV3 in skin physiology and pathology, including barrier formation, hair growth, inflammation, and itching. Finally, we examine the potential of TRPV3 as a therapeutic target for skin diseases and highlight its diverse role in maintaining skin homeostasis.

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“…No. AM2222 and 4368813) on an Applied Biosystems 2720 Thermal Cycler (Thermo Fisher Scientific), according to the manufacturer's protocols [88][89][90][91][92]96].…”

Section: Rna Isolation and Reverse Transcriptionmentioning

confidence: 99%

N,N-Dimethylglycine Sodium Salt Exerts Marked Anti-Inflammatory Effects in Various Dermatitis Models and Activates Human Epidermal Keratinocytes by Increasing Proliferation, Migration, and Growth Factor Release

Lendvai,

Béke,

Hollósi

et al. 2023

IJMS

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N,N-dimethylglycine (DMG) is a naturally occurring compound being widely used as an oral supplement to improve growth and physical performance. Thus far, its effects on human skin have not been described in the literature. For the first time, we show that N,N-dimethylglycine sodium salt (DMG-Na) promoted the proliferation of cultured human epidermal HaCaT keratinocytes. Even at high doses, DMG-Na did not compromise the cellular viability of these cells. In a scratch wound-closure assay, DMG-Na augmented the rate of wound closure, demonstrating that it promotes keratinocyte migration. Further, DMG-Na treatment of the cells resulted in the upregulation of the synthesis and release of specific growth factors. Intriguingly, DMG-Na also exerted robust anti-inflammatory and antioxidant effects, as assessed in three different models of human keratinocytes, mimicking microbial and allergic contact dermatitis as well as psoriasis and UVB irradiation-induced solar dermatitis. These results identify DMG-Na as a highly promising novel active compound to promote epidermal proliferation, regeneration, and repair, and to exert protective functions. Further preclinical and clinical studies are under investigation to prove the seminal impact of topically applied DMG-Na on relevant conditions of the skin and its appendages.

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Transient receptor potential vanilloid 3 expression is increased in non‐lesional skin of atopic dermatitis patients

Cited by 9 publications

References 33 publications

Heat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway

Heat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway

Unlocking the therapeutic potential of TRPV3: Insights into thermosensation, channel modulation, and skin homeostasis involving TRPV3

N,N-Dimethylglycine Sodium Salt Exerts Marked Anti-Inflammatory Effects in Various Dermatitis Models and Activates Human Epidermal Keratinocytes by Increasing Proliferation, Migration, and Growth Factor Release

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