2005
DOI: 10.1074/jbc.m501229200
|View full text |Cite
|
Sign up to set email alerts
|

Transient Receptor Potential Vanilloid Type 1 Activation Down-regulates Voltage-gated Calcium Channels through Calcium-dependent Calcineurin in Sensory Neurons

Abstract: Calcium influx through voltage-activated Ca2؉ channels (VACCs) plays a critical role in neurotransmission. Capsaicin application inhibits VACCs and desensitizes nociceptors. In this study, we determined the signaling mechanisms of the inhibitory effect of capsaicin on VACCs in primary sensory neurons. Whole-cell voltage clamp recordings were performed in acutely isolated rat dorsal root ganglion neurons. Capsaicin caused a profound decrease in the Ca TRPV11 is a nonselective cation channel with high Ca 2ϩ per… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

11
108
2

Year Published

2008
2008
2024
2024

Publication Types

Select...
9

Relationship

1
8

Authors

Journals

citations
Cited by 107 publications
(121 citation statements)
references
References 50 publications
11
108
2
Order By: Relevance
“…RTX is a well-known capsaicin analogue, and its binding is competitively inhibited by the TRPV1 antagonist capsazepine (Szallasi and Blumberg, 1999). RTX treatment can activate TRPV1 and rapidly kill primary afferent neurons through calcium influx and overloading (Olah et al, 2001;Wu et al, 2005). Our immunocytochemistry data confirmed that RTX eliminated presynaptic δ-opioid receptors on TRPV1-immunoreactive DRG neurons and their terminals in the spinal dorsal horn.…”
Section: Discussionsupporting
confidence: 72%
“…RTX is a well-known capsaicin analogue, and its binding is competitively inhibited by the TRPV1 antagonist capsazepine (Szallasi and Blumberg, 1999). RTX treatment can activate TRPV1 and rapidly kill primary afferent neurons through calcium influx and overloading (Olah et al, 2001;Wu et al, 2005). Our immunocytochemistry data confirmed that RTX eliminated presynaptic δ-opioid receptors on TRPV1-immunoreactive DRG neurons and their terminals in the spinal dorsal horn.…”
Section: Discussionsupporting
confidence: 72%
“…In contrast, previous attempts have not identified any effect of TRPV1 activation on synaptic inhibition (Yang et al, 1998;Marinelli et al, 2003;D.P. Li et al, 2004;Xing and Li, 2007).…”
Section: Discussionmentioning
confidence: 89%
“…5). Notably, CaN has been involved in TRPV1-mediated downregulation of voltage-gated Ca 2ϩ channels in primary sensory neurons (Wu et al, 2005) and TRPV1-induced LTD in hippocampal interneurons (Jensen and Edwards, 2012). Together, these observations substantiate the notion that CaN is a common downstream target of TRPV1-mediated effects.…”
Section: Discussionmentioning
confidence: 99%
“…Accordingly, CB 1 Rs can negatively control TRPV 1 Rs in a Ca 2+ -dependent manner, preventing the contrasting co-activation of the ionotropic partner (Marinelli et al, 2005;Oshita et al, 2005;Wu et al, 2005;Mahmud et al, 2009;Yang et al, 2013).…”
Section: Introductionmentioning
confidence: 99%