Transient seizure onset network for localization of epileptogenic zone: effective connectivity and graph theory-based analyses of ECoG data in temporal lobe epilepsy

Abstract

Highlights  Origination and propagation of epileptic activities could be observed with the high temporal resolution of the full-frequency adaptive directed transfer function (ffADTF) effective connectivity networks.  The seizure-specific transient seizure onset ffADTF network remained for approximately 20-50 ms with strong connections generated from both the seizure onset zone (SOZ) and epileptogenic zone (EZ).  The ffADTF combined with the graph metrics in the transient seizure onset network can provide a more precise localization of the SOZ and EZ.  Out-degree and clustering coefficient were found to be more closely correlated with the clinically determined SOZ and EZ than closeness centrality, betweenness centrality and local efficiency in the low-frequency δ and θ bands than in the α, β and γ frequency bands in seizure-free patients postoperatively.

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