Transition from rest to movement: Brain correlates revealed by functional connectivity

Treserras, Sébastien; Boulanouar, Kader; Conchou, Fabrice; Simonetta‐Moreau, Marion; Berry, Isabelle; Celsis, Pierre; Chollet, François; Loubinoux, Isabelle

doi:10.1016/j.neuroimage.2009.06.016

Cited by 44 publications

(60 citation statements)

References 59 publications

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“…Cojan et al argued that self-monitoring processes, generally associated with the DMN and with the precuneus, dominate the control of the paralysed hand due to an altered internal representation of the self, caused by hypnotic suggestion or to certain memories related to the self (Cojan et al, 2009a;Cojan et al, 2009b). Our observations of an increased functional connectivity between PCC/PCu and the upper part of BA 7 during hypnosis are perfectly in line with those of Cojan et al and Treserras et al (Cojan et al, 2009a;Cojan et al, 2009b;Treserras et al, 2009). Our observation suggests that movement representation is altered in hypnotic paralysis, and that this alteration is closely related to the self-referential function of the PCC/PCu.…”

Section: Connectivity Of the Posterior Cingulate Cortex And Precuneussupporting

confidence: 91%

“…The degree of self-relatedness to presented images is correlated with the activation of the ventro-and dorsomedial prefrontal cortex and the posterior cingulate cortex in the subsequent rest phase (Schneider et al, 2008). Furthermore, subjects shifting from a pure resting state to a movement-readiness condition revealed a stronger functional coupling of the lower part of the precuneus with an upper area of the precuneus and motor related cortices (Treserras et al, 2009). Considering that further studies found the precuneus to be involved in motor execution and imagery (Hanakawa et al, 2003;Hanakawa et al, 2008;Meister et al, 2004;Wager et al, 2004) and functionally connected with motor areas in hysterical conversion paralysis (Cojan et al, 2009a), the DMN, and in particular the precuneus, appears to be the controlling unit when prospective thoughts and self-referential processes include motor related actions.…”

Section: Introductionmentioning

confidence: 93%

“…Furthermore, it is more active when attentional demands are needed to perform motor actions from information stored in working memory (Luo et al, 2004;Wager et al, 2005). Treserras et al (2009) found that the DMN and the motor network are functionally connected through the medial superior parietal cortex in the upper precuneus (BA 7) during movement readiness. Based on the model of motor control developed by (Brooks, 1986), they suggest that overlapping areas of the motor and default mode network are activated in the preparatory state before movement execution, possibly allowing a transfer of information from one network to the other.…”

Section: Connectivity Of the Posterior Cingulate Cortex And Precuneusmentioning

confidence: 99%

“…Based on the model of motor control developed by (Brooks, 1986), they suggest that overlapping areas of the motor and default mode network are activated in the preparatory state before movement execution, possibly allowing a transfer of information from one network to the other. This transfer might occur between the lower PCC/PCu area, which belongs to the DMN, and the upper PCC/PCu area involved in motor imagery (BA 7) (Treserras et al, 2009). Furthermore, activation of this area increases and is more strongly coupled with M1 when the execution hand is paralysed by hypnosis (Cojan, et al, 2009b) or by hysterical conversion paralysis (Cojan, et al, 2009a).…”

Section: Connectivity Of the Posterior Cingulate Cortex And Precuneusmentioning

confidence: 99%

“…The PCC/PCu area is known to be related to self-monitoring processes and consciousness of self (Cavanna et al, 2006;D'Argembeau et al, 2005;Luo et al, 2004;Rameson et al, 2009;van Buuren et al, in press). The increased connectivity between PCC/PCu and the right DLPFC at rest may represent the functional correlate of altered internal movement representation (Cojan et al, 2009b;Treserras et al, 2009). As the DLPFC is related to cognitive control, including self-control processes (Badre and Wagner, 2004;Dehaene and Changeux, 1995;Hare et al, 2009), the increased PCC/ PCu-DLPFC connectivity may be a neurobiological correlate of selfcontrol processes maintaining hypnotic paralysis.…”

Section: Connectivity Of the Posterior Cingulate Cortex And Precuneusmentioning

confidence: 99%

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Brain correlates of hypnotic paralysis—a resting-state fMRI study

et al. 2011

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Section: Connectivity Of the Posterior Cingulate Cortex And Precuneussupporting

confidence: 91%

Section: Introductionmentioning

confidence: 93%

Section: Connectivity Of the Posterior Cingulate Cortex And Precuneusmentioning

confidence: 99%

Section: Connectivity Of the Posterior Cingulate Cortex And Precuneusmentioning

confidence: 99%

Section: Connectivity Of the Posterior Cingulate Cortex And Precuneusmentioning

confidence: 99%

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Brain correlates of hypnotic paralysis—a resting-state fMRI study

et al. 2011

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The functional connectivity of intralaminar thalamic nuclei in the human basal ganglia

Rodriguez-Sabate

Llanos

Moráles

et al. 2014

Human Brain Mapping

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Projections of the centromedian-parafasicularis neurons of the intralaminar thalamus are major inputs of the striatum. Their functional role in the activity of human basal ganglia (BG) is not well known. The aim of this work was to study the functional connectivity of intralaminar thalamic nuclei with other BG by using the correlations of the BOLD signal recorded during "resting" and a motor task. Intralaminar nuclei showed a marked functional connectivity with all the tested BG, which was observed during "resting" and did not change with the motor task. As regards the intralaminar nuclei, BG connectivity was much lower for the medial dorsal nucleus (a thalamic nucleus bordering the intralaminar nuclei) and for the default mode network (although intralaminar nuclei showed a negative correlation with the default mode network). After the "regression" of intralaminar nuclei activity (partial correlation), the functional connectivity of the caudate and putamen nuclei with other BG decreased (but not with the primary sensorimotor cortex). Present data provide evidence that intralaminar nuclei are not only critical for striatal activity but also for the global performance of human BG, an action involving subcortical BG loops more than cortico-subcortical loops. The high correlation found between BG suggest that, similarly to that reported in other brain centers, the very-slow frequency fluctuations are relevant for the functional activity of these centers.

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Conscious but not thinking—Mind‐blanks during visuomotor tracking: An fMRI study of endogenous attention lapses

Zaky,

Shoorangiz,

Poudel

et al. 2024

Human Brain Mapping

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Attention lapses (ALs) are complete lapses of responsiveness in which performance is briefly but completely disrupted and during which, as opposed to microsleeps, the eyes remain open. Although the phenomenon of ALs has been investigated by behavioural and physiological means, the underlying cause of an AL has largely remained elusive. This study aimed to investigate the underlying physiological substrates of behaviourally identified endogenous ALs during a continuous visuomotor task, primarily to answer the question: Were the ALs during this task due to extreme mind‐wandering or mind‐blanks? The data from two studies were combined, resulting in data from 40 healthy non‐sleep‐deprived subjects (20M/20F; mean age 27.1 years, 20–45). Only 17 of the 40 subjects were used in the analysis due to a need for a minimum of two ALs per subject. Subjects performed a random 2‐D continuous visuomotor tracking task for 50 and 20 min in Studies 1 and 2, respectively. Tracking performance, eye‐video, and functional magnetic resonance imaging (fMRI) were recorded simultaneously. A human expert visually inspected the tracking performance and eye‐video recordings to identify and categorise lapses of responsiveness as microsleeps or ALs. Changes in neural activity during 85 ALs (17 subjects) relative to responsive tracking were estimated by whole‐brain voxel‐wise fMRI and by haemodynamic response (HR) analysis in regions of interest (ROIs) from seven key networks to reveal the neural signature of ALs. Changes in functional connectivity (FC) within and between the key ROIs were also estimated. Networks explored were the default mode network, dorsal attention network, frontoparietal network, sensorimotor network, salience network, visual network, and working memory network. Voxel‐wise analysis revealed a significant increase in blood‐oxygen‐level‐dependent activity in the overlapping dorsal anterior cingulate cortex and supplementary motor area region but no significant decreases in activity; the increased activity is considered to represent a recovery‐of‐responsiveness process following an AL. This increased activity was also seen in the HR of the corresponding ROI. Importantly, HR analysis revealed no trend of increased activity in the posterior cingulate of the default mode network, which has been repeatedly demonstrated to be a strong biomarker of mind‐wandering. FC analysis showed decoupling of external attention, which supports the involuntary nature of ALs, in addition to the neural recovery processes. Other findings were a decrease in HR in the frontoparietal network before the onset of ALs, and a decrease in FC between default mode network and working memory network. These findings converge to our conclusion that the ALs observed during our task were involuntary mind‐blanks. This is further supported behaviourally by the short duration of the ALs (mean 1.7 s), which is considered too brief to be instances of extreme mind‐wandering. This is the first study to demonstrate that at least the majority of complete losses of responsiveness on a continuous visuomotor task are, if not due to microsleeps, due to involuntary mind‐blanks.

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Transition from rest to movement: Brain correlates revealed by functional connectivity

Cited by 44 publications

References 59 publications

Brain correlates of hypnotic paralysis—a resting-state fMRI study

Brain correlates of hypnotic paralysis—a resting-state fMRI study

The functional connectivity of intralaminar thalamic nuclei in the human basal ganglia

Conscious but not thinking—Mind‐blanks during visuomotor tracking: An fMRI study of endogenous attention lapses

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