Transition From Temporary to Durable Circulatory Support Systems

Saeed, Diyar; Potapov, Evgenij; Loforte, Antonio; Morshuis, Michiel; Schibilsky, David; Zimpfer, Daniel; Riebandt, Julia; Pappalardo, Federico; Attisani, Matteo; Rinaldi, Mauro; Haneya, Assad; Ramjankhan, Faiz; Donker, Dirk W.; Jorde, Ulrich P.; Stein, Julia; Tsyganenko, Dmytro; Jawad, Khalil; Wieloch, R.; Ayala, Rafael; Cremer, Jochen; Borger, Michael A.; Lichtenberg, Artur; Gummert, Jan

doi:10.1016/j.jacc.2020.10.036

Cited by 41 publications

(35 citation statements)

References 23 publications

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“…Although the primary therapeutic goal is bridging to myocardial recovery and weaning from the device, bridging to durable mechanical circulatory support (MCS) or heart transplantation is an option for eligible patients when ECLS weaning is unlikely or unsuccessful. 4,5 Despite technical and medical advances, the mortality of PC-ECLS patients remains high with reported in-hospital survival rates ranging from 25% to 46%. [6][7][8][9][10][11] Furthermore, PC-ECLS is associated with a number of potentially devastating complications that may arise during therapy and limit outcome, some of which are directly related to the site of cannulation, including limb ischemia and cannulation site bleeding.…”

Section: See Commentary On Page XXXmentioning

confidence: 99%

Access site complications of postcardiotomy extracorporeal life support

Schaefer

Distelmaier

Riebandt

et al. 2022

The Journal of Thoracic and Cardiovascular Surgery

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Section: See Commentary On Page XXXmentioning

confidence: 99%

Access site complications of postcardiotomy extracorporeal life support

Schaefer

Distelmaier

Riebandt

et al. 2022

The Journal of Thoracic and Cardiovascular Surgery

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“…14 Similar results were obtained in a recent European multicenter study in which the 30-day and 1-year survival rates in patients with ECLS support who underwent left ventricular VAD implantation were 77% and 53%, respectively. 15 Therefore, evaluation of the risk of adverse outcome before VAD implantation is important.…”

Section: 6mentioning

confidence: 99%

“…16 An RFSS of seven or more -composed of parameters reflecting lung dysfunction, systemic infection, serum lactate, creatinine kinase and kidney dysfunction-could be attributed to a poor outcome. 16 In 15 Based on these weighted parameters, a risk-calculation model was developed.…”

Section: 6mentioning

confidence: 99%

We Enter the Bridge and Start to Run Out of Time

Morshuis

Erdoes

Koster

et al. 2022

Journal of Cardiothoracic and Vascular Anesthesia

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“…We were able to identify several survival predictors. An app "Durable MCS after ECLS calculator" was introduced that aids future patient selection and helps to avoid unnecessary resource utilization (4).…”

Section: Introductionmentioning

confidence: 99%

Impact of extra-corporeal life support (ECLS) cannulation strategy on outcome after durable mechanical circulation support system implantation on behalf of durable MCS after ECLS Study Group

Saeed¹,

Potapov²,

Loforte³

et al. 2021

Ann Cardiothorac Surg

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Background: The literature on outcomes of patients requiring durable mechanical circulatory support (MCS) after extra-corporeal life support (ECLS) is limited. The aim of this study was to investigate the impact of preoperative ECLS cannulation on postoperative outcome after durable MCS implantation. Methods:The durable MCS after ECLS registry is a multicenter retrospective study that gathered data on consecutive patients who underwent durable MCS implantation after ECLS between January 2010 and August 2018 in eleven high volume European centers. Patients who underwent the implantation of total artificial heart, pulsatile pumps, or first-generation pumps after ECLS were excluded from the analysis. The remaining patients were divided into two groups; central ECLS group (cECLS) and peripheral ECLS group (pECLS). A 1:1 propensity score analysis was performed to identify two matched groups. The outcome of these two groups was compared.Results: A total of 531 durable MCS after ECLS were implanted during this period. The ECLS cannulation site was peripheral in 87% (n=462) and central in 13% (n=69) of the patients. After excluding pulsatile pumps and total artificial heart patients, a total of 494 patients remained (pECLS =434 patients, cECLS =60 patients). A 1:1 propensity score analysis resulted in 2 matched groups (each 55 patients) with median age of 54 years (48-60 years) in cECLS group and 54 years (43-60 years) in pECLS group.HeartWare HVAD (Medtronic, Minneapolis, MN) was implanted in the majority of the patients (cECLS =71% vs. pECLS =76%, P=0.67). All postoperative morbidities were comparable between the groups. The thirty-day, one year and long-term survival was comparable between the groups (P=0.73). Conclusions:The cannulation strategy of ECLS appears to have no impact on the post-operative outcome after durable MCS implantation.

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Transition From Temporary to Durable Circulatory Support Systems

Cited by 41 publications

References 23 publications

Access site complications of postcardiotomy extracorporeal life support

Access site complications of postcardiotomy extracorporeal life support

We Enter the Bridge and Start to Run Out of Time

Impact of extra-corporeal life support (ECLS) cannulation strategy on outcome after durable mechanical circulation support system implantation on behalf of durable MCS after ECLS Study Group

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