Transition metal catalysed alkylation of pyridines and indoles

Catalytic Addition of C – H Bonds to C – C Multiple Bonds

“…2) [28]. This result indicates that C -C bond formation takes place preferentially at the electrondeficient aromatic ring.…”

CH Bond Alkylation (Including Hydroarylation of Alkenes)

“…In addition, Grigg and Savic [83] showed that the reaction of benzoylpyridines with triethoxyvinylsilane occurs ortho to the acetyl group on the more electron-deficient pyridine ring (Scheme 19.50). Using the Murai reaction, Weber et al…”

Recent advances in the C–H-functionalization of the distal positions in pyridines and quinolines

“…74 They surmised that an acetyl group could direct the substitution at either C3 or C4 faster than at the C2 position.…”