Transition Metal‐Catalyzed CH Bond Functionalization Involving Metal Migration

Abstract

Transition metal‐catalyzed CH functionalization has become a pivotal organic transformation in the past decades. Numerous methodologies involving transition metal migrations have evolved into novel and significant synthetic tools for the introduction of metallic moiety into positions that have challenged traditional methods. The metal migration process is accompanied by concurrent migration of a hydrogen atom in the direction opposite to that of the metal migration. The current article provides an overview of catalytic CH functionalization involving 1,4‐ and 1,5‐metal‐migration processes with a focus on Pd‐ and Rh‐catalyzed reactions to demonstrate the synthetic power of such strategies.