Transition Metals in Personal Samples of PM2.5 and Oxidative Stress in Human Volunteers

Sørensen, Mette; Schins, Roel P. F.; Hertel, Ole; Loft, Steffen

doi:10.1158/1055-9965.epi-04-0899

Cited by 136 publications

(79 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The first finding regarding coal extraction, was a systemic OS present in the blood or workers directly or indirectly exposed to PM emissions related to coal mining [1], in general accordance to the related literature [10,13,16]. More importantly, they also revealed that people living in the vicinity (ca.…”

Section: After the Antioxidant Interventionsupporting

confidence: 63%

“…In particular, chronic inhalation of coal dust in miners leads to several diseases such as pneumoconiosis, fibrosis, bronchitis, emphysema, cancer and other pathologic-related events [16]. In any case, a chronic inflammatory process takes place, leading to the generation of proinflammatory factors, synthesis of extra cellular matrix, fibroblast proliferation, and altering the prooxidant/antioxidant balance, therefore producing OS resulting in lung damage, even after cessation of exposure to the contaminants [17][18][19].…”

Section: Before the Antioxidant Interventionmentioning

confidence: 99%

See 1 more Smart Citation

Systemic Oxidative Stress Promoted by Emissions of Particulate Matter is Attenuated by Antioxidant Supplementation

Possamai¹,

Avila²,

Filho³

2015

eee

View full text Add to dashboard Cite

Emissions of different types of airborne particulate matter (PM) is associated either with occupational contamination that affect both, workers directly exposed to the distinct PM sources such as incineration of solid residues of health services, coal mining and also coal burning derived from an electric-power plant, as well as the population living in the vicinity of such emissions. Such contamination leads to endogenous overgeneration of reactive oxygen species (ROS) in different cells and tissues and therefore to a systemic oxidative stress (OS). Enzymatic and non-enzymatic OS biomarkers were measured in the blood of workers directly and indirectly (near the emissions) exposed and also in subjects indirectly exposed living in the vicinities of these PM emissions, before and after a six months antioxidant intervention of a daily oral supplementation of vitamins C (500 mg) and E (400 mg). Compared to baseline values, the antioxidant intervention after 6 months was able to confer a consistent and protective effect against the systemic OS irrespective of the PM source of the airborne contaminants. The results clearly indicate that supplementation with antioxidant vitamins could be recommended in order to attenuate the deleterious consequences of a systemic OS associated with such PM emissions.

show abstract

Section: After the Antioxidant Interventionsupporting

confidence: 63%

Section: Before the Antioxidant Interventionmentioning

confidence: 99%

Systemic Oxidative Stress Promoted by Emissions of Particulate Matter is Attenuated by Antioxidant Supplementation

Possamai¹,

Avila²,

Filho³

2015

eee

View full text Add to dashboard Cite

show abstract

“…The lung content in chromate workers with lung cancer is 0.7 mM, compared to control, 0.004 mM (non-chromate lung cancer) (Tsuneta et al, 1980). The personal exposure to ambient particulate matter may be equivalent in content to 0.11 mM Cr and 0.11 mM V (Sorensen et al, 2005).…”

Section: Resultsmentioning

confidence: 90%

Effects of hTERT on metal ion-induced genomic instability

et al. 2006

View full text Add to dashboard Cite

There is currently a great interest in delayed chromosomal and other damaging effects of low-dose exposure to a variety of pollutants which appear collectively to act through induction of stress-response pathways related to oxidative stress and ageing. These have been studied mostly in the radiation field but evidence is accumulating that the mechanisms can also be triggered by chemicals, especially heavy metals. Humans are exposed to metals, including chromium (Cr) (VI) and vanadium (V) (V), from the environment, industry and surgical implants. Thus, the impact of low-dose stress responses may be larger than expected from individual toxicity projections. In this study, a short (24 h) exposure of human fibroblasts to low doses of Cr (VI) and V (V) caused both acute chromosome damage and genomic instability in the progeny of exposed cells for at least 30 days after exposure. Acutely, Cr (VI) caused chromatid breaks without aneuploidy while V (V) caused aneuploidy without chromatid breaks. The longerterm genomic instability was similar but depended on hTERT positivity. In telomerase-negative hTERTÀ cells, Cr (VI) and V (V) caused a long lasting and transmissible induction of dicentric chromosomes, nucleoplasmic bridges, micronuclei and aneuploidy. There was also a long term and transmissible reduction of clonogenic survival, with an increased b-galactosidase staining and apoptosis. This instability was not present in telomerasepositive hTERT þ cells. In contrast, in hTERT þ cells the metals caused a persistent induction of tetraploidy, which was not noted in hTERTÀ cells. The growth and survival of both metal-exposed hTERT þ and hTERTÀ cells differed if they were cultured at subconfluent levels or plated out as colonies. Genomic instability is considered to be a driving force towards cancer. This study suggests that the type of genomic instability in human cells may depend critically on whether they are telomerase-positive or -negative and that their sensitivities to metals could depend on whether they are clustered or diffuse.

show abstract

“…8OHdG in urine has been positively correlated in the past with PM 10 and PM 2.5 exposure, [76] with the heavy-metal content of aerosol, [77,78] with Hg in the environment, [79] and with lifestyle factors on a variety of confidence levels. Table 4 .…”

Section: Biological Effects and Correlation Of Aerosolmentioning

confidence: 99%

Probing Functional Groups at the Gas–Aerosol Interface Using Heterogeneous Titration Reactions: A Tool for Predicting Aerosol Health Effects?

et al. 2010

View full text Add to dashboard Cite

The complex chemical and physical nature of combustion and secondary organic aerosols (SOAs) in general precludes the complete characterization of both bulk and interfacial components. The bulk composition reveals the history of the growth process and therefore the source region, whereas the interface controls--to a large extent--the interaction with gases, biological membranes, and solid supports. We summarize the development of a soft interrogation technique, using heterogeneous chemistry, for the interfacial functional groups of selected probe gases [N(CH(3))(3), NH(2)OH, CF(3)COOH, HCl, O(3), NO(2)] of different reactivity. The technique reveals the identity and density of surface functional groups. Examples include acidic and basic sites, olefinic and polycyclic aromatic hydrocarbon (PAH) sites, and partially and completely oxidized surface sites. We report on the surface composition and oxidation states of laboratory-generated aerosols and of aerosols sampled in several bus depots. In the latter case, the biomarker 8-hydroxy-2'-deoxyguanosine, signaling oxidative stress caused by aerosol exposure, was isolated. The increase in biomarker levels over a working day is correlated with the surface density N(i)(O3) of olefinic and/or PAH sites obtained from O(3) uptakes as well as with the initial uptake coefficient, γ(0), of five probe gases used in the field. This correlation with γ(0) suggests the idea of competing pathways occurring at the interface of the aerosol particles between the generation of reactive oxygen species (ROS) responsible for oxidative stress and cellular antioxidants.

show abstract

Transition Metals in Personal Samples of PM2.5 and Oxidative Stress in Human Volunteers

Cited by 136 publications

References 26 publications

Systemic Oxidative Stress Promoted by Emissions of Particulate Matter is Attenuated by Antioxidant Supplementation

Systemic Oxidative Stress Promoted by Emissions of Particulate Matter is Attenuated by Antioxidant Supplementation

Effects of hTERT on metal ion-induced genomic instability

Probing Functional Groups at the Gas–Aerosol Interface Using Heterogeneous Titration Reactions: A Tool for Predicting Aerosol Health Effects?

Contact Info

Product

Resources

About