Transition of the abnormal Savda syndrome to the hepatic carcinoma shifted unfolded protein response to autophagy was partly reversed by Savda Munziq in a rat model

ASMq protects against early burn wound progression in rats by alleviating oxidative stress and secondary mitochondria‑associated apoptosis via the Erk/p90RSK/Bad pathway

“…There is a complementary balance between these fluids, which serves a role in the maintenance of normal physiology and the occurrence and development of disease. When the internal environment changes, these four body fluids become AS, which can be harmful to various organs (10). With advancements of science and technology, research into Uyghur traditional medicine has become more in-depth, with significant progress in drug extraction and component analysis (33)(34)(35).…”

“…With advancements of science and technology, research into Uyghur traditional medicine has become more in-depth, with significant progress in drug extraction and component analysis (33)(34)(35). ASMq, a natural compound of traditional Uyghur Medicine, has been reported to exhibit anti-inflammatory, antioxidant and anti-apoptotic effects, and decreases oxidative damage by free radicals (10)(11)(12)(13)(14)(15)(16)(17). The production of ASMq is subject to a patent application (no.…”

“…Abnormal Savda Munziq (ASMq), a traditional herbal formula in Uyghur medicine, primarily consists of ten herbs, including Lavandula angustifolia, Foeniculum vulgare, Anchusa italica, Euphorbia humifusae, Melissa officinalis, Adiantum capillus-veneris, Glycyrrhiza uralensis, Cordia dichotoma, Ziziphus jujuba and Alhagi pseudoalhagi (10). Previous reports demonstrated that ASMq exerts antioxidative, anti-inflammatory and anti-apoptotic properties to inhibit the formation of hypertrophic scars (4) and treat diabetes, cardiovascular disease, pulmonary disorders and various types of cancer, such as cervical cancer and hepatic carcinoma (10)(11)(12)(13)(14)(15)(16)(17); to the best of our knowledge, however, few studies have investigated its potential effects on burn injury. In consideration of the critical role of reactive oxygen species (ROS)-induced ASMq protects against early burn wound progression in rats by alleviating oxidative stress and secondary mitochondria-associated apoptosis via the Erk/p90RSK/Bad pathway oxidative stress and subsequent mitochondria-associated apoptosis in the pathophysiological development of early burn wounds, it was hypothesized that ASMq may prevent early burn wound progression in rats by suppressing oxidative stress and apoptosis.…”