Transition to Fast Whole-Body SPECT/CT Bone Imaging: An Assessment of Image Quality

Alqahtani, Mansour M.; Willowson, Kathy; Fulton, Roger; Constable, Chris; Kench, Peter

doi:10.3390/diagnostics12122938

Cited by 5 publications

(3 citation statements)

References 22 publications

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“…They discovered that image quality is not compromised with short scanning times because fast SPECT provides more information than planar studies. This new protocol is considered state-of-the-art and should be incorporated into routine clinical practice (8).…”

Section: Discussionmentioning

confidence: 99%

“…Long scanning time can also result in false SUV measurements in the case of SPECT quantification. Many studies highlight the potential of scan time reduction without degradation of image quality because new, more sensitive detector systems with advanced software applications (iterative reconstruction with resolution recovery) have been developed for new fast SPECT scanning protocols (8). New protocols suggest that planar WB scintigraphy should be replaced with WB SPECT/CT.…”

Section: Introductionmentioning

confidence: 99%

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Optimisation of the bone single photon emission computed tomography in oncology patients

Salkica,

Begić,

Beganović

et al. 2024

JHSCI

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Introduction: The introduction of hybrid imaging systems such as Single Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) has completely changed the scanning procedure of conventional diagnostic nuclear medicine protocols. Modern bone scintigraphy protocols include SUV quanitification and Whole Body (WB) SPECT/CT scanning modality. The major limitation of these new technologies is relatively long scanning time. New detector systems with modern reconstruction softwares have been developed for fast scanning SPECT protocolos. These new technologies can produce images of reduced acquisition with same quality as full scanning acquisition. As a result new studies suggest that planar WB scintigraphy should be replaced with WB SPECT/CT. Methods: One hundred oncology patients performed SPECT/CT as a part as their clinical follow-up. Three different scanning and three reconstruction protocols have been evaluated. Two nuclear medicine physicians evaluated with Likert scale image sharpness, lesion visibility, and lesion background detectability. The overall image quality was determined as the sum of these three parameters. Results: In terms of scan duration reduction on image quality, Volumetrix Evolution for Bone performed during ultra-fast SPECT acquisition achieved the highest score, which is superior compared to the standard SPECT acquisition protocol. The overall image quality was the best with the Volumetrix MI Evolution for Bone protocol for ultra-fast acquisition Conclusion: The Evolution for Bone protocol for ultra-fast acquisition showed best results compared to other protocols. The adoption of new acquisition SPECT protocol may offer more comfortable exams, resulting in higher patient satisfaction. The implementation of this new protocol can lead to an improvement in SPECT sensitivity, primarily due to the reduction of SPECT motion artifacts.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Optimisation of the bone single photon emission computed tomography in oncology patients

Salkica,

Begić,

Beganović

et al. 2024

JHSCI

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“…This is not an uncommon trend, as Tc-99m HMDP bone scintigraphy is relatively cheap and can be totally performed during an ambulatory visit, due to its short duration and low risk [17,18]. In addition, some studies suggest that both scan time and injected dose, may be reduced without jeopardizing diagnosis [19,20]. The higher incidence of extravasation found in inpatient setting could be explained by the utilization of preexisting peripheral venous catheters for radiopharmaceutical injection.…”

Section: Discussionmentioning

confidence: 99%

Radiopharmaceutical extravasation in bone scintigraphy: a cross-sectional study

Fernandes

Santos

Pinheiro

et al. 2023

Nuclear Medicine Communications

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Objetives Tc-99m Hydroxymethylene diphosphonate (HMDP) bone scintigraphy is commonly used to diagnose bone disorders. We aimed to quantify and characterize the occurrence of radiopharmaceutical extravasation in bone scintigraphy, using Tc-99m HMDP, as well as to compare the visual classification of the events with an independent analysis using image processing software. Methods We conducted a cross-sectional study, using data from a total of 400 (9.1%) exams, randomly selected from all the procedures performed in 2018 in the Portuguese Institute of Oncology of Porto, Portugal. Prevalence estimate and the corresponding 95% confidence interval (CI) was computed for the presence of extravasation. Odds ratios and 95% CI were computed to quantify the association between demographic and clinical characteristics, and the occurrence of extravasation. Results The prevalence of Tc-99m HMDP extravasation was 26.5% (95% CI: 22.4−31.0). Those from an inpatient setting had almost seven-fold higher odds of extravasation than those from an outpatient setting. When the wrist was used for administration, there was three times more odds of extravasation when compared to the use of hand. There were statistically significant differences in the median scores of extravasations severity obtained from image processing software according to the different grades attributed by visual appreciation (P < 0.001). Conclusion Tc-99m HMDP extravasation occurred in one out of four patients, being more frequent among those from an inpatient setting and when the wrist was used for administration. Visual appreciation of the extravasation seems to be acceptable to classify its severity.

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Gallium oxide semiconductor-based large volume ultrafast radiation hard spectroscopic scintillators

Datta,

Mei,

Lebedinsky

et al. 2024

Journal of Applied Physics

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We report on the development of the first-ever inorganic radiation-hard moisture-insensitive large volume spectroscopic semiconductor-based scintillator with less than 2 ns decay time and light yields as high as 8000 ph/MeV. Despite extensive research into scintillator materials, the quest for an ideal scintillator combining ultrafast decay times (akin to BaF2 and Yb-doped scintillators such as Lu2O3:Yb), high light yields (exceeding 2000 photons per MeV), spectroscopic capabilities, and exceptional radiation hardness remain unfulfilled. In this study, we demonstrate and report for the first time the viability of large-volume (up to 20 mm thickness) gallium oxide (β-Ga2O3) semiconductor-based scintillators for applications requiring these properties. These β-Ga2O3 scintillators were grown using the fast turnaround (∼2 days) crucible-free optical float zone (FZ) technique. The high light yield and ultrafast decay time of these high-purity n-type semiconductors with free carrier concentration of 6 × 1017 cm−3 are attributed to native defects, specifically oxygen vacancies (VO) and gallium–oxygen vacancy pairs (VGa–VO), generated during optimized FZ growth. The ultrafast decay, along with high light yield, enables excellent timing resolution and high count rate detection for applications like time-of-flight positron emission tomography, physics experiments, and nuclear safety. The radiation hardness of these devices has been documented in a separate publication.

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Transition to Fast Whole-Body SPECT/CT Bone Imaging: An Assessment of Image Quality

Cited by 5 publications

References 22 publications

Optimisation of the bone single photon emission computed tomography in oncology patients

Optimisation of the bone single photon emission computed tomography in oncology patients

Radiopharmaceutical extravasation in bone scintigraphy: a cross-sectional study

Gallium oxide semiconductor-based large volume ultrafast radiation hard spectroscopic scintillators

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