Transitional cell carcinoma matrix stiffness regulates the osteopontin and YAP expression in recurrent patients

Ghasemi, Hadi; Mousavi-Bahar, Seyed Habibollah; Hashemnia, Mohammad; Karimi, Jamshid; Khodadadi, Iraj; Tavilani, Heidar

doi:10.1007/s11033-021-06440-8

Cited by 10 publications

(9 citation statements)

References 44 publications

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“…The role of YAP in BC has received increasing attention, and many studies have shown that YAP is a clinical marker of BC progression (44) and a key molecule contributing to postoperative recurrence and chemotherapy resistance in BC (45). Levels of YAP correlate positively with pathological grade The Hippo pathway's upstream serine-threonine kinase cascade regulates YAP/TAZ.…”

Section: Aberrant Activation Of Yap/taz In Bcmentioning

confidence: 99%

“…Fortunately, according to the latest research, it has been found that the integrin-FAK-CDC42-PP1A (45)signaling pathway leads to ECM stiffness to promote the progression and recurrence of BC (Figure 3C). In addition to the high expression of b1-integrin (encoded by ITGB1), FAK, and CDC42, high ECM stiffness is also associated with increased nuclear localization of YAP (45). Molecular docking data showed that integrin binds to FAK through hydrogen bonding (45).…”

Section: Ecm Stiffness Activates Yapmentioning

confidence: 99%

“…In addition to the high expression of b1-integrin (encoded by ITGB1), FAK, and CDC42, high ECM stiffness is also associated with increased nuclear localization of YAP (45). Molecular docking data showed that integrin binds to FAK through hydrogen bonding (45). FAK activates CDC42-PP1A kinase and dephosphorylates YAP (85), thus increasing the nuclear localization of YAP (45).…”

Section: Ecm Stiffness Activates Yapmentioning

confidence: 99%

“…Molecular docking data showed that integrin binds to FAK through hydrogen bonding (45). FAK activates CDC42-PP1A kinase and dephosphorylates YAP (85), thus increasing the nuclear localization of YAP (45).…”

Section: Ecm Stiffness Activates Yapmentioning

confidence: 99%

“…Overexpression of YAP was verified, and current studies indicated that YAP has a more extensive contribution to the development of BC. YAP plays a key role in BC initiation, progression, chemoresistance, and induction of BCSCs (44,45,47,55). Interestingly, multiple mechanisms are now found to be involved in YAP upregulation in BC.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

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Clinical potential of the Hippo-YAP pathway in bladder cancer

et al. 2022

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Bladder cancer (BC) is one of the world’s most frequent cancers. Surgery coupled with adjuvant platinum-based chemotherapy is the current standard of therapy for BC. However, a high proportion of patients progressed to chemotherapy-resistant or even neoplasm recurrence. Hence, identifying novel treatment targets is critical for clinical treatment. Current studies indicated that the Hippo-YAP pathway plays a crucial in regulating the survival of cancer stem cells (CSCs), which is related to the progression and reoccurrence of a variety of cancers. In this review, we summarize the evidence that Hippo-YAP mediates the occurrence, progression and chemotherapy resistance in BC, as well as the role of the Hippo-YAP pathway in regulating bladder cancer stem-like cells (BCSCs). Finally, the clinical potential of Hippo-YAP in the treatment of BC was prospected.

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Section: Aberrant Activation Of Yap/taz In Bcmentioning

confidence: 99%

Section: Ecm Stiffness Activates Yapmentioning

confidence: 99%

Section: Ecm Stiffness Activates Yapmentioning

confidence: 99%

Section: Ecm Stiffness Activates Yapmentioning

confidence: 99%

Section: Conclusion and Perspectivementioning

confidence: 99%

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Clinical potential of the Hippo-YAP pathway in bladder cancer

et al. 2022

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Trends in extracellular matrix biology

et al. 2022

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Extracellular matrixes (ECMs) are intricate 3-dimensional macromolecular networks of unique architectures with regulatory roles in cell morphology and functionality. As a dynamic native biomaterial, ECM undergoes constant but tightly controlled remodeling that is crucial for the maintenance of normal cellular behavior. Under pathological conditions like cancer, ECM remodeling ceases to be subjected to control resulting in disease initiation and progression. ECM is comprised of a staggering number of molecules that interact not only with one another, but also with neighboring cells via cell surface receptors. Such interactions, too many to tally, are of paramount importance for the identification of novel disease biomarkers and more personalized therapeutic intervention. Recent advances in big data analytics have allowed the development of online databases where researchers can take advantage of a stochastic evaluation of all the possible interactions and narrow them down to only those of interest for their study, respectively. This novel approach addresses the limitations that currently exist in studies, expands our understanding on ECM interactions, and has the potential to advance the development of targeted therapies. In this article we present the current trends in ECM biology research and highlight its importance in tissue integrity, the main interaction networks, ECM-mediated cell functional properties and issues related to pharmacological targeting.

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Mechanobiology of solid tumors

Gargalionis

Papavassiliou

2022

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Transitional cell carcinoma matrix stiffness regulates the osteopontin and YAP expression in recurrent patients

Cited by 10 publications

References 44 publications

Clinical potential of the Hippo-YAP pathway in bladder cancer

Clinical potential of the Hippo-YAP pathway in bladder cancer

Trends in extracellular matrix biology

Mechanobiology of solid tumors

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