[Translated article] Aquagenic Keratoderma: Treatment Update

Successful treatment of aquagenic keratoderma with botulinum toxin injections

“…The lesions may be itchy and painful. The goal of treatment is to eliminate lesions and improve patient comfort [1].…”

“…Zmianom może towarzyszyć bolesność i świąd. Celem leczenia jest eliminacja zmian skórnych i poprawa komfortu pacjenta [1].…”

“…Pacjentka zauważyła znaczące ustąpienie objawów już po tygodniu od wstrzyknięcia toksyny botulinowej. Pełna odpowiedź kliniczna Dermatology Review/Przegląd Dermatologiczny 2022/5 characterized by translucent, white-colored papules, plaques and edema on the palms develop in minutes following exposure to water [1,2]. The lesions may lead to itching, pain, tightness and burning sensation [3,4].…”

“…The exact cause of aquagenic keratoderma remains unknown [4]. However, it has been associated with cystic fibrosis, palmar hyperhidrosis and medications such as acetylsalicylic acid, paracetamol, sulfasalazine and tobramycin [1][2][3][4][5]. The diagnosis of aquagenic keratoderma is usually made based on clinical features since histopathological examination does not provide a specific finding [2].…”

“…Topical aluminum chloride hexahydrate, urea, salicylic acid, oral oxybutynin, acitretin, iontophoresis and thoracic sympathectomy are the choice of treatment. A few cases treated with botulinum toxin have also been reported [1][2][3][4][5]. However, treatment of aquagenic keratoderma is troublesome since no effective medication with a low risk of adverse events has been proposed for aquagenic keratoderma [1].…”