Translating airway biomarker information into practice: From theoretical science to applied medicine

Ameredes, Bill T.

doi:10.1016/j.pupt.2010.09.006

Cited by 1 publication

(1 citation statement)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent emphasis has been placed on the assessment of biomarkers in the determination of disease, drug, and toxicity effects. 42 Interestingly, some asthmatic patients carry a genetic polymorphism linked to the bronchial hyper-responsiveness that is triggered by exposure to SO 2 . 43 For example, the study by Winterton et al (2001) sought to determine which genetic polymorphism might be responsible for this reaction, and they found that 13 of 62 asthmatic subjects screened had decreased FEV 1 of 12% or greater, as compared to baseline, following inhalation of 500 ppb (0.5 ppm) SO 2 for 10 minutes.…”

Section: -mentioning

confidence: 99%

Mechanisms of Heightened Airway Sensitivity and Responses to Inhaled SO₂in Asthmatics

Reno

Brooks

Ameredes

2015

Environ�Health�Insights

Self Cite

View full text Add to dashboard Cite

Sulfur dioxide (SO2) is a problematic inhalable air pollutant in areas of widespread industrialization, not only in the United States but also in countries undergoing rapid industrialization, such as China, and it can be a potential trigger factor for asthma exacerbations. It is known that asthmatics are sensitive to the effects of SO2; however, the basis of this enhanced sensitivity remains incompletely understood. A PubMed search was performed over the course of 2014, encompassing the following terms: asthma, airway inflammation, sulfur dioxide, IL-10, mouse studies, and human studies. This search indicated that biomarkers of SO2 exposure, SO2 effects on airway epithelial cell function, and animal model data are useful in our understanding of the body’s response to SO2, as are SO2-associated amplification of allergic inflammation, and potential promotion of neurogenic inflammation due to chemical irritant properties. While definitive answers are still being sought, these areas comprise important foci of consideration regarding asthmatic responses to inhaled SO2. Furthermore, IL-10 deficiency associated with asthma may be another important factor associated with an inability to resolve inflammation and mitigate oxidative stress resulting from SO2 inhalation, supporting the idea that asthmatics are predisposed to SO2 sensitivity, leading to asthma exacerbations and airway dysfunction.

show abstract

Section: -mentioning

confidence: 99%

Mechanisms of Heightened Airway Sensitivity and Responses to Inhaled SO₂in Asthmatics

Reno

Brooks

Ameredes

2015

Environ�Health�Insights

Self Cite

View full text Add to dashboard Cite

show abstract

Translating airway biomarker information into practice: From theoretical science to applied medicine

Cited by 1 publication

References 48 publications

Mechanisms of Heightened Airway Sensitivity and Responses to Inhaled SO₂in Asthmatics

Mechanisms of Heightened Airway Sensitivity and Responses to Inhaled SO₂in Asthmatics

Contact Info

Product

Resources

About

Translating airway biomarker information into practice: From theoretical science to applied medicine

Cited by 1 publication

References 48 publications

Mechanisms of Heightened Airway Sensitivity and Responses to Inhaled SO2in Asthmatics

Mechanisms of Heightened Airway Sensitivity and Responses to Inhaled SO2in Asthmatics

Contact Info

Product

Resources

About

Mechanisms of Heightened Airway Sensitivity and Responses to Inhaled SO₂in Asthmatics

Mechanisms of Heightened Airway Sensitivity and Responses to Inhaled SO₂in Asthmatics