“…Only one of the articles included informed that the study sample had not been randomized 22 . Four of the studies were described by their authors as single-blind 13,14,18,22 , five did not include information about whether they were doubleblind trials or not 7,18 27,32,34 , and one informed that the trial was "not double-blind". In respect to the study design, only two articles did not describe the inclusion of comparison groups 25,30 .…”