Translationally controlled tumor protein: the mediator promoting cancer invasion and migration and its potential clinical prospects

Gao, Junying; Ma, Yan; Yang, Guiwen; Li, Guorong

doi:10.1631/jzus.b2100910

Cited by 8 publications

(10 citation statements)

References 86 publications

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“…TCT-1 (TCTP) encodes a multifunctional protein that interacts with many other proteins (Gao et al, 2022). TCTP has been implicated in cell invasion in human cancer cells in vitro , potentially through promoting a range of activities, including MMP expression and interactions with actin and microtubule regulators (Bae et al, 2015; Gao et al, 2022). To gain insight into how TCT-1 fosters invasion through BM in vivo , we used an AC-specific RNAi strain and confirmed that TCT-1 functions in the AC to promote invasion (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…TCTP’s promiscuity likely underlies its influence on numerous cellular processes, including cell growth, cell division, apoptosis, and response to cell stress (Bommer and Telerman, 2020). TCTP is overexpressed in most tumors, is associated with poor patient prognosis, and is being targeted in cancer clinical trials (Boia-Ferreira et al, 2017; Bommer, 2017; Gao et al, 2022; Karaki et al, 2017). Although strongly implicated in metastasis (Gao et al, 2022; Zhang et al, 2017), a role for TCTP in BM invasion has been difficult to establish because of the challenges of studying BM transmigration in vivo .…”

Section: Discussionmentioning

confidence: 99%

“…TCTP is overexpressed in most tumors, is associated with poor patient prognosis, and is being targeted in cancer clinical trials (Boia-Ferreira et al, 2017; Bommer, 2017; Gao et al, 2022; Karaki et al, 2017). Although strongly implicated in metastasis (Gao et al, 2022; Zhang et al, 2017), a role for TCTP in BM invasion has been difficult to establish because of the challenges of studying BM transmigration in vivo . TCTP regulates the function of many key molecular components of BM invasion, such as actin and microtubule associated proteins, GTPases, and MMP expression (Bae et al, 2015; Bazile et al, 2009; Zhang et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…TCTP is overexpressed in most tumors, is associated with poor patient prognosis, and is being targeted in cancer clinical trials (Boia-Ferreira et al, 2017; Bommer, 2017; Gao et al, 2022; Karaki et al, 2017). Although strongly implicated in metastasis (Gao et al, 2022; Zhang et al, 2017), a role for TCTP in BM invasion has not been establish in vivo . Through endogenous tagging and AC-specific RNAi, we found that TCT-1 (TCTP) is present at high levels in the AC cytoplasm and functions within the AC to promote invasion.…”

Section: Discussionmentioning

confidence: 99%

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TheC. elegansAnchor Cell Transcriptome: Ribosome Biogenesis Drives Cell Invasion through Basement Membrane

Costa

Kenny-Ganzert

Chi

et al. 2022

Preprint

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Cell invasion through basement membrane (BM) barriers is important in development, immune function, and cancer progression. As invasion through BM is often stochastic, capturing gene expression profiles of cells actively transmigrating BM in vivo remains elusive. Using the stereotyped timing of C. elegans anchor cell (AC) invasion, we generated an AC transcriptome during BM breaching. Through a focused RNAi screen of transcriptionally enriched genes, we identified new invasion regulators, including TCTP (Translationally Controlled Tumor Protein). We also discovered gene enrichment of ribosomal proteins. AC-specific RNAi, endogenous ribosome labeling, and ribosome biogenesis analysis revealed a burst of ribosome production occurs shortly after AC specification, which drives the translation of proteins mediating BM removal. Ribosomes also strongly localize to the ACs endoplasmic reticulum (ER) and the endomembrane system expands prior to invasion. We show that AC invasion is sensitive to ER stress, indicating a heightened requirement for translation of ER trafficked proteins. These studies reveal key roles for ribosome biogenesis and endomembrane expansion in cell invasion through BM and establish the AC transcriptome as a resource to identify mechanisms underlying BM transmigration.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…TCTP is overexpressed in most tumors, is associated with poor patient prognosis, and is being targeted in cancer clinical trials (Boia-Ferreira et al, 2017; Bommer, 2017; Gao et al, 2022; Karaki et al, 2017). Although strongly implicated in metastasis (Gao et al, 2022; Zhang et al, 2017), a role for TCTP in BM invasion has not been establish in vivo . Through endogenous tagging and AC-specific RNAi, we found that TCT-1 (TCTP) is present at high levels in the AC cytoplasm and functions within the AC to promote invasion.…”

Section: Discussionmentioning

confidence: 99%

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