Transmembrane Signaling with Lipid‐Bilayer Assemblies as a Platform for Channel‐Based Biosensing

Abstract

Artificial and natural lipid membranes that elicit transmembrane signaling is are useful as a platform for channel-based biosensing. In this account we summarize our research on the design of transmembrane signaling associated with lipid bilayer membranes containing nanopore-forming compounds. Channel-forming compounds, such as receptor ion-channels, channel-forming peptides and synthetic channels, are embedded in planar and spherical bilayer lipid membranes to develop highly sensitive and selective biosensing methods for a variety of analytes. The membrane-bound receptor approach is useful for introducing receptor sites on both planar and spherical bilayer lipid membranes. Natural receptors in biomembranes are also used for designing of biosensing methods.

Enhanced Stability of Lipid Structures by Dip-Pen Nanolithography on Block-Type MPC Copolymer

“…Phospholipid membranes play a key role in living systems, as they are the way cells delineate themselves from the outside built compartments for different functions within the cell and are even used for communication purposes [ 1 , 2 ]. This eminent role leads to big interest in artificial biomimetic phospholipid membranes that have then been used in biosensors [ 3 , 4 , 5 ], membrane-protein research [ 6 ] and other biological applications [ 7 , 8 ]. Supported lipid bilayers (SLBs) are a subset of these biomimetic membranes that is particularly interesting for arraying and studies of biological interactions [ 9 ].…”