Transmission electron microscopy study of the effects of cadmium and copper on fetal rat liver tissue

Oğuz, E.; Abban, Gülçin; Kutlubay, Recep; Turgut, Sebahat; Enli, Yaşar; Erdoğan, Deniz

doi:10.1007/bf02686024

Cited by 6 publications

(2 citation statements)

References 22 publications

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“…The liver is one of the main organs where Cd builds up and as such, is the target of its toxicity. The exposure of Wistar rats to drinking water containing 10 mg/kg CdCl 2 during gestation causes degenerative changes in hepatocytes of fetuses at term, such as dilation of the smooth endoplasmic reticulum, slightly damaged nuclear membranes, and mitochondrial dilation [ 125 ]. In addition, a higher dose of Cd (50 ppm CdCl 2 ) changes the hepatic mRNA and protein levels of the glucocorticoid receptor due to modifications of the level of methylation on its promoter region.…”

Section: Effects Of CD In the Fetal Organismmentioning

confidence: 99%

Cadmium Handling, Toxicity and Molecular Targets Involved during Pregnancy: Lessons from Experimental Models

Jacobo-Estrada

Santoyo-Sánchez

Thévenod

et al. 2017

IJMS

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Even decades after the discovery of Cadmium (Cd) toxicity, research on this heavy metal is still a hot topic in scientific literature: as we wrote this review, more than 1440 scientific articles had been published and listed by the website during 2017. Cadmium is one of the most common and harmful heavy metals present in our environment. Since pregnancy is a very particular physiological condition that could impact and modify essential pathways involved in the handling of Cd, the prenatal life is a critical stage for exposure to this non-essential element. To give the reader an overview of the possible mechanisms involved in the multiple organ toxic effects in fetuses after the exposure to Cd during pregnancy, we decided to compile some of the most relevant experimental studies performed in experimental models and to summarize the advances in this field such as the Cd distribution and the factors that could alter it (diet, binding-proteins and membrane transporters), the Cd-induced toxicity in dams (preeclampsia, fertility, kidney injury, alteration in essential element homeostasis and bone mineralization), in placenta and in fetus (teratogenicity, central nervous system, liver and kidney).

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Section: Effects Of CD In the Fetal Organismmentioning

confidence: 99%

Cadmium Handling, Toxicity and Molecular Targets Involved during Pregnancy: Lessons from Experimental Models

Jacobo-Estrada

Santoyo-Sánchez

Thévenod

et al. 2017

IJMS

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“…In addition, high concentrations of Cd inhibit basal respiration ( 19 ). Moreover, Cd can directly damage the mitochondrial structures in the liver, causing mitochondrial degeneration, vacuolation, and disruption of the mitochondrial membrane structure ( 20 , 21 ). In the presence of severe mitochondrial damage, the process of mitochondrial autophagy is activated.…”

Section: Introductionmentioning

confidence: 99%

Whole Transcriptome Profiling of the Effects of Cadmium on the Liver of the Xiangxi Yellow Heifer

Wei

Yi²,

Shen

et al. 2022

Front. Vet. Sci.

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Cadmium (Cd) is a major heavy metal toxicant found in industrial zones. Humans and animals are exposed to it through their diet, which results in various physiological problems. In the current study, the toxic effects of Cd on the liver were investigated by whole-transcriptome sequencing (RNA-seq) of the livers of Xiangxi heifers fed a diet with excess Cd. We randomly divided six healthy heifers into two groups. The first group received a control diet, whereas the second group received Cd-exceeding diets for 100 days. After 100 days, the livers were collected. A total of 551 differentially expressed mRNAs, 24 differentially expressed miRNAs, and 169 differentially expressed lncRNAs were identified (p < 0.05, |log2FC| >1). Differentially expressed genes (DEGs) were analyzed by gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses. We found that under Cd exposure, DEGs were enriched in the adenosine 5'-monophosphate–activated protein kinase pathway, which is involved in autophagy regulation, and the peroxisome proliferator–activated receptor pathway, which is involved in lipid metabolism. In addition, the apolipoprotein A4 gene, which has anti-inflammatory and antioxidant effects, the anti-apoptotic gene ATPase H+/K+ transporting the nongastric alpha2 subunit, and the cholesterol metabolism–associated gene endothelial lipase gene were significantly downregulated. C–X–C motif chemokine ligand 3, cholesterol 7α-hydroxylase, and stearoyl-CoA desaturase, which are involved in the development of fatty liver, were significantly upregulated. These genes revealed the main effects of Cd on the liver of Xiangxi yellow heifers. The current study provides insightful information regarding the DEGs involved in autophagy regulation, apoptosis, lipid metabolism, anti-inflammation, and antioxidant enzyme activity. These may serve as useful biomarkers for predicting and treating Cd-related diseases in the future.

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High-dose copper activates p53-independent apoptosis through the induction of nucleolar stress in human cell lines

et al. 2021

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Transmission electron microscopy study of the effects of cadmium and copper on fetal rat liver tissue

Cited by 6 publications

References 22 publications

Cadmium Handling, Toxicity and Molecular Targets Involved during Pregnancy: Lessons from Experimental Models

Cadmium Handling, Toxicity and Molecular Targets Involved during Pregnancy: Lessons from Experimental Models

Whole Transcriptome Profiling of the Effects of Cadmium on the Liver of the Xiangxi Yellow Heifer

High-dose copper activates p53-independent apoptosis through the induction of nucleolar stress in human cell lines

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